{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:40:25Z","timestamp":1771519225633,"version":"3.50.1"},"reference-count":70,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To summarize what we know so far about coronavirus disease (COVID\u201019) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We searched PubMed, Scientific Electronic Library Online, and Latin American and Caribbean Center on Health Sciences Information from 1 January\u00a02020 to 4 May\u00a02020. We selected randomized trials, observational studies, case series or case reports, and research letters of children ages birth to 18 years with laboratory\u2010confirmed COVID\u201019. We conducted random\u2010effects meta\u2010analyses to calculate the weighted mean prevalence and 95% confidence interval (CI) or the weighted average means and 95% CI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Forty\u2010six articles reporting 551 cases of COVID\u201019 in children (aged 1 day\u201017.5\u00a0years) were included. Eighty\u2010seven percent (95% CI: 77%\u201095%) of patients had household exposure to COVID\u201019. The most common symptoms and signs were fever (53%, 95% CI: 45%\u201061%), cough (39%, 95% CI: 30%\u201047%), and sore throat\/pharyngeal erythema (14%, 95% CI: 4%\u201028%); however, 18% (95% CI: 11%\u201027%) of cases were asymptomatic. The most common radiographic and computed tomography (CT) findings were patchy consolidations (33%, 95% CI:\u00a023%\u201043%) and ground glass opacities (28%, 95% CI: 18%\u201039%), but 36% (95% CI: 28%\u201045%) of patients had normal CT images. Antiviral agents were given to 74% of patients (95% CI:\u00a052%\u201092%). Six patients, all with major underlying medical conditions, needed invasive mechanical ventilation, and one of them died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Previously healthy children with COVID\u201019 have mild symptoms. The diagnosis is generally suspected from history of household exposure to COVID\u201019 case. Children with COVID\u201019 and major underlying condition are more likely to have severe\/critical disease and poor prognosis, even death.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24869","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T10:24:12Z","timestamp":1591784652000},"page":"2115-2127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["What we know so far about Coronavirus Disease 2019 in children: A meta\u2010analysis of 551 laboratory\u2010confirmed cases"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-5840","authenticated-orcid":false,"given":"Linjie","family":"Zhang","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology Unit, Faculty of Medicine Federal University of Rio Grande Rio Grande Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyele G.","family":"Peres","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Faculty of Medicine Federal University of Rio Grande Rio Grande Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus V. 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