{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:16:21Z","timestamp":1768252581348,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nonsteroidal anti\u2010inflammatory drugs, such as selective phosphodiesterase type 4 (PDE4) inhibitors have potential anti\u2010inflammatory and respiratory smooth muscle relaxation effects. This study aimed to investigate the pathophysiological effects of an intravenous PDE4 inhibitor (rolipram) and surfactant lavage (SL) in a newborn piglet model of meconium aspiration syndrome (MAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MAS was induced in 25 newborn piglets, which were randomly divided into control and four SL treatment groups administered with different doses of intravenous rolipram (0, 0.1, 0.5, and 1\u2009mg\/kg). Cardiopulmonary variables were monitored and recorded. The experimental time was 4\u2009hours. Serial blood was drawn for blood gas and biomarker analyses. Lung tissue was examined for histological analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All SL\u2010treated groups revealed improved oxygenation during the 4\u2010hour experiments and had significantly lower peak inspiratory pressure levels than the control group at the end of experiments. All SL plus rolipram\u2010treated groups exhibited significantly higher lung compliance than the control group. However, the animals receiving high\u2010dose (0.5 and 1.0\u2009mg\/kg) rolipram demonstrated significantly elevated heart rates. Lung histology of the nondependent sites revealed significantly lower lung injury scores in all SL\u2010treated groups compared with that in the control group, but there were no differences among the rolipram\u2010treated groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In addition to SL, intravenous PDE4 inhibitors may further improve lung compliance in treating MAS; however, it is necessary to consider cardiovascular adverse effects, primarily tachycardia. Further investigations are required before the clinical application of intravenous PDE4 inhibitor as an anti\u2010inflammatory agent to treat severe MAS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24880","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T13:34:09Z","timestamp":1591018449000},"page":"2272-2282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pathophysiological effects of intravenous phosphodiesterase type 4 inhibitor in addition to surfactant lavage in meconium\u2010injured newborn piglet lungs"],"prefix":"10.1002","volume":"55","author":[{"given":"Wei\u2010Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics,\u00a0Children's Medical Center Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Emergency and Critical Care Medicine, School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Department of Pediatrics School of Medicine, National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hsueh","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nutrition Master Program of BioMedical Nutrition, HungKuang University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Sheng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Children's Medical Center Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Pediatrics School of Medicine, National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Chen","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Children's Medical Center Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Pediatrics 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