{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T15:57:06Z","timestamp":1770566226941,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>Pulmonary complications are the leading cause of morbidity and mortality in sickle cell disease (SCD) patients. Research in SCD has predominantly been conducted on African\u2010Americans, and the disease burden of SCD in other races and ethnicities, including Hispanic patients, is not well characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare pulmonary disease burden between Hispanic and non\u2010Hispanic ethnic groups among children with SCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective chart review on 566 SCD patients followed at the Children's Hospital at Montefiore, NY, we compared the pulmonary disease burden and disease management in Hispanic patients to their non\u2010Hispanic counterparts. We also compared the contribution of demographic and clinical variables to acute chest syndrome (ACS), vaso\u2010occlusive crisis (VOC), and hospitalizations for SCD related complications between the two ethnic groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hispanic patients had a greater proportion of ACS, and had lower forced expiratory volume (FEV1), forced vital capacity, and vital capacity, compared to non\u2010Hispanics. Hispanic patients were more likely to be evaluated in pulmonary clinic and to be on inhaled corticosteroids, short\u2010acting \u03b2 agonizts, and leukotriene receptor antagonists. In addition, Hispanic children were more likely to be on hydroxyurea, and receive exchange transfusions. However, the association of asthma with the proportion of ACS did not differ between Hispanics and non\u2010Hispanics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hispanic children with SCD had differences in their pulmonary function profile and received more pulmonary evaluations than non\u2010Hispanic children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24883","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T18:08:08Z","timestamp":1591121288000},"page":"2064-2073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pulmonary disease burden in Hispanic and non\u2010Hispanic children with sickle cell disease"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1793-0293","authenticated-orcid":false,"given":"Laura","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Pediatric Respiratory and Sleep Medicine Children's Hospital at Montefiore  Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Medicine Albert Einstein College of Medicine  Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Matta","sequence":"additional","affiliation":[{"name":"Division of Pediatric Respiratory and Sleep Medicine Children's Hospital at Montefiore  Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry","family":"Morrone","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Children's Hospital at Montefiore  Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Manwani","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Children's Hospital at Montefiore  Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5714-9250","authenticated-orcid":false,"given":"Deepa","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's National Health System  Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliva","family":"De","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Columbia University Medical Center Vagelos College of Physicians and Surgeons  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25450"},{"key":"e_1_2_7_3_1","volume-title":"Sickle Cell Anemia: Risk Factors?","author":"National Heart, Lung, and Blood Institute"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-2082CI"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2013.10.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000756"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2009.1.45"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.029165"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000212968.98501.2b"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20430"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.123"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.128"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201401-0186PP"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950150204"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9712108"},{"issue":"6","key":"e_1_2_7_16_1","first-page":"893","article-title":"Reference values for pulmonary tissue volume, membrane diffusing capacity, and pulmonary capillary blood volume","volume":"18","author":"Crapo RO","year":"1982","journal-title":"Bull Eur Physiopathol Respir"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/isbn.978-3-318-04125-5","volume-title":"Lung Function in Children and Adolescents: Methods, Reference Values","author":"Zapletal A","year":"1987"},{"issue":"3","key":"e_1_2_7_18_1","first-page":"270","article-title":"Single breath diffusing capacity in a representative sample of the population of Michigan, a large industrial state","volume":"127","author":"Miller A","year":"1983","journal-title":"Am Rev Respir Dis"},{"issue":"6","key":"e_1_2_7_19_1","first-page":"974","article-title":"Longitudinal changes in forced expiratory volume in one second in adults. 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