{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:28:14Z","timestamp":1779301694444,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD058818"],"award-info":[{"award-number":["R01HD058818"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have shown that exposure to air pollutants affects lung growth and development and can result in poor respiratory health in early life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included a subsample of 772 Mexican preschoolers whose mothers participated in a Prenatal Omega\u20103 fatty acid Supplements, GRowth, And Development birth cohort study with the aim to evaluate the impact of prenatal exposure to volatile organic compounds and nitrogen oxides on lung function measured by oscillation tests. The preschoolers were followed until 5 years of age. Anthropometric measurements and forced oscillation tests were performed at 36, 48, and 60 months of age. Information on sociodemographic and health characteristics was obtained during follow up. Prenatal exposure to volatile organic compounds and nitrogen oxides was evaluated using a land use regression models and the association between them was tested using a lineal regression and longitudinal linear mixed effect models adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the mean (standard deviation) of the measurements of respiratory system resistance and respiratory system reactance at 6, 8, and 10\u2009Hz during the follow\u2010up period was 11.3 (2.4), 11.1 (2.4), 10.3 (2.2) and \u20135.2 (1.6), \u20134.8 (1.7), and \u20134.6 hPa\u2009s\u2009L<jats:sup>\u22121<\/jats:sup> (1.6), respectively. We found a significantly positive association between respiratory resistance (<jats:italic>\u03b2<\/jats:italic><jats:sub>Rrs6<\/jats:sub>\u2009=\u20090.011; 95%CI: 0.001, 0.023) (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) and prenatal exposure to nitrogen dioxide and a marginally negatively association between respiratory reactance (<jats:italic>\u03b2<\/jats:italic><jats:sub>Xrs6<\/jats:sub>\u2009=\u2009\u221211.40 95%CI: \u221225.26, 1.17 and <jats:italic>\u03b2<\/jats:italic><jats:sub>Xrs8<\/jats:sub>\u2009=\u2009\u221211.91 95%CI: \u221226.51, 1.43) (<jats:italic>P<\/jats:italic>\u2009=\u2009.07) and prenatal exposure to xylene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prenatal exposure to air pollutants was significantly associated with the alteration of lung function measured by oscillation tests in these preschool children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24889","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T11:07:46Z","timestamp":1591614466000},"page":"2142-2149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prenatal exposure to VOCs and NOx and lung function in preschoolers"],"prefix":"10.1002","volume":"55","author":[{"given":"Rosa I.","family":"Guti\u00e9rrez\u2010Delgado","sequence":"first","affiliation":[{"name":"Departamento de Salud Ambiental Instituto Nacional de Salud P\u00fablica  Cuernavaca Morelos Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-4175","authenticated-orcid":false,"given":"Albino","family":"Barraza\u2010Villarreal","sequence":"additional","affiliation":[{"name":"Departamento de Salud Ambiental Instituto Nacional de Salud P\u00fablica  Cuernavaca Morelos Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda C.","family":"Escamilla\u2010N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Departamento de Salud Ambiental Instituto Nacional de Salud P\u00fablica  Cuernavaca Morelos Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-2758","authenticated-orcid":false,"given":"Leticia","family":"Hern\u00e1ndez\u2010Cadena","sequence":"additional","affiliation":[{"name":"Departamento de Salud Ambiental Instituto Nacional de Salud P\u00fablica  Cuernavaca Morelos Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2363-8061","authenticated-orcid":false,"given":"Marlene","family":"Cortez\u2010Lugo","sequence":"additional","affiliation":[{"name":"Departamento de Salud Ambiental Instituto Nacional de Salud P\u00fablica  Cuernavaca Morelos Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6305-2201","authenticated-orcid":false,"given":"Peter","family":"Sly","sequence":"additional","affiliation":[{"name":"Department of Children's Health and Environment The University of Queensland  Brisbane Queensland Australia"},{"name":"WHO Collaborating Centre for Research on Children's Environmental Health  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-5273","authenticated-orcid":false,"given":"Isabelle","family":"Romieu","sequence":"additional","affiliation":[{"name":"Departamento de Salud Ambiental Instituto Nacional de Salud P\u00fablica  Cuernavaca Morelos Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"144","article-title":"Principales causas de mortalidad infantil en M\u00e9xico: tendencias recientes","volume":"69","author":"Fern\u00e1ndez\u2010Cant\u00f3n SB","year":"2012","journal-title":"Bol Med Hosp Infant Mex"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015381"},{"key":"e_1_2_8_4_1","unstructured":"SUIVE\/DGE\/SALUD.Informaci\u00f3n epidemiol\u00f3gica de morbilidad. 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