{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:22Z","timestamp":1740104122300,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evidence for nocturnal oximetry interpretation in patients with abnormal neuromuscular function is limited. We aimed to compare children with neuromuscular disease (NMD) or Prader\u2010Willi syndrome (PWS) to otherwise healthy subjects with obstructive sleep\u2010disordered breathing (SDB) or without respiratory disorder (controls) regarding nocturnal oximetry parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed recordings from children with: (a) NMD; (b) PWS; (c) snoring and adenotonsillar hypertrophy and\/or obesity (SDB); and (d) controls. Outcomes included: (a) basal SpO<jats:sub>2<\/jats:sub>; (b) proportions of subjects with McGill oximetry score (MOS) &gt;1 (clusters of desaturations); and (c) desaturation index (SpO<jats:sub>2<\/jats:sub> drops \u22653%\/h\u2010ODI3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data of 12 subjects with NMD (median age, 5.2 years; IQR, 2.7, 8.2), 14 children with PWS (5 years; 2.3, 6.9), 21 children with SDB (5.8 years; 4.6, 9.6), and 20 controls (6.2 years; 5.4, 11.2) were analyzed. Children with NMD, PWS, and SDB had lower basal SpO<jats:sub>2<\/jats:sub> than controls (95.6% [94.5%, 96.9%], 96.2% [95.1%, 97.4%], 96.1% [95.8%, 97.5%] vs 97.8% [97.2%, 97.9%], respectively; (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). NMD and PWS showed the greatest negative effect on basal SpO<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Children with SDB or PWS had a higher risk of MOS &gt;1 than patients with NMD (OR, 25.9 [95% CI, 3.4\u2010200.4] and 9.5 [1.5\u201062.6]). NMD, PWS, and SDB were similar regarding ODI3, which was elevated compared to ODI3 in controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Frequent desaturations predominated in NMD, while periods of sustained desaturation were noted in NMD and PWS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PWS and NMD have a negative effect on basal SpO<jats:sub>2<\/jats:sub>, while clusters of desaturations are prevalent in patients with PWS or obstructive SDB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24899","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T15:00:52Z","timestamp":1591887652000},"page":"2089-2096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Measures of nocturnal oxyhemoglobin desaturation in children with neuromuscular disease or Prader\u2010Willi syndrome"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3592-0037","authenticated-orcid":false,"given":"Athanasios G.","family":"Kaditis","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonology and Sleep Disorders Laboratory, First Department of Pediatrics National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Polytarchou","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology and Sleep Disorders Laboratory, First Department of Pediatrics National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aggeliki","family":"Moudaki","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology and Sleep Disorders Laboratory, First Department of Pediatrics National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polytimi","family":"Panaghiotopoulou\u2010Gartagani","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology and Sleep Disorders Laboratory, First Department of Pediatrics National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Kanaka\u2010Gantenbein","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology and Sleep Disorders Laboratory, First Department of Pediatrics National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital  Athens 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