{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:15:33Z","timestamp":1761156933898,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bacterial infection early in life may increase structural lung lesions in children with cystic fibrosis (CF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 9\u2010year monocentric (Bordeaux University Hospital, France) retrospective study in children with CF to evaluate the impact of the early\u2010onset (at 1 year of age, Y1) of chronic meticillin\u2010sensitive <jats:italic>Staphylococcus aureus<\/jats:italic> (MSSA) infection on the severity of bronchiectasis and Bhalla score on CT scan, clinical status, lung function tests, and serum immunoglobulins (IgG) at the age of 6 years (Y6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 37 children were included: 10 had contracted chronic MSSA infection at Y1 and 27 at a later date. Children with MSSA infection at Y1 showed increased Y6 CT scan bronchiectasis severity scores vs late MSSA infection (mean\u2009\u00b1\u2009SD: 4.7\u2009\u00b1\u20090.8 vs 2.5\u2009\u00b1\u20090.5, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) and Bhalla scores (7.3\u2009\u00b1\u20091.1 vs 4.7\u2009\u00b1\u20090.8, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), but no significant decrease in lung function ([% reference values] FEV1: 83.7\u2009\u00b1\u20096 vs 90.6\u2009\u00b1\u20092.2, <jats:italic>P<\/jats:italic>\u2009=\u2009.21; FEF25\u201075: 67.8\u2009\u00b1\u20098.9 vs 76.3\u2009\u00b1\u20093.9, <jats:italic>P<\/jats:italic>\u2009=\u2009.18). In addition, Y6 serum IgG was greater in the early chronic Y1 MSSA group (11.3\u2009\u00b1\u20090.7 vs 8.9\u2009\u00b1\u20090.7\u2009g\/L, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Clinical symptoms or nutritional status were similar in both infection groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early chronic MSSA infection may enhance the progression of structural lung disease in CF at 6 years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24906","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T14:21:59Z","timestamp":1592317319000},"page":"2641-2645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact at school age of early chronic methicillin\u2010sensitive <i>Staphylococcus aureus<\/i> infection in children with cystic fibrosis"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-4514","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Galod\u00e9","sequence":"first","affiliation":[{"name":"Imaging Department, CF\u2010Center, Clinical Investigation Centre, Pellegrin\u2010Enfants Hospital Bordeaux University Hospital Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0251-6639","authenticated-orcid":false,"given":"Gael","family":"Dournes","sequence":"additional","affiliation":[{"name":"Imaging Department, CF\u2010Center, Clinical Investigation Centre, Pellegrin\u2010Enfants Hospital Bordeaux University Hospital Bordeaux France"},{"name":"Laboratory of Cellular Respiratory Physiology, Centre de Recherche Cardio\u2010Thoracique de Bordeaux, INSERM U1045 University Bordeaux Segalen Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6143-7607","authenticated-orcid":false,"given":"Jean\u2010Fran\u00e7ois","family":"Chateil","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Respiratory Physiology, Centre de Recherche Cardio\u2010Thoracique de Bordeaux, INSERM U1045 University Bordeaux Segalen Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1238-2128","authenticated-orcid":false,"given":"Michael","family":"Fayon","sequence":"additional","affiliation":[{"name":"Imaging Department, CF\u2010Center, Clinical Investigation Centre, Pellegrin\u2010Enfants Hospital Bordeaux University Hospital Bordeaux France"},{"name":"Laboratory of Cellular Respiratory Physiology, Centre de Recherche Cardio\u2010Thoracique de Bordeaux, INSERM U1045 University Bordeaux Segalen Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrielle","family":"Collet","sequence":"additional","affiliation":[{"name":"Imaging Department, CF\u2010Center, Clinical Investigation Centre, Pellegrin\u2010Enfants Hospital Bordeaux University Hospital Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3576-2518","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Bui","sequence":"additional","affiliation":[{"name":"Imaging Department, CF\u2010Center, Clinical Investigation Centre, Pellegrin\u2010Enfants Hospital Bordeaux University Hospital Bordeaux France"},{"name":"Laboratory of Cellular Respiratory Physiology, Centre de Recherche Cardio\u2010Thoracique de Bordeaux, INSERM U1045 University Bordeaux Segalen Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22863"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00043108"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2010.88"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2011.06.002"},{"key":"e_1_2_8_6_1","unstructured":"UK Cystic Fibrosis Trust Antibiotic Group.Antibiotic Treatment for Cystic Fibrosis. 3rd ed. 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