{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:09:07Z","timestamp":1758823747273,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Current evidence supports nasal continuous positive airway pressure (NCPAP) weaning. Heated humidified high\u2010flow nasal cannula (HHFNC) reduces NCPAP time in infants less than 28 weeks gestational age (GA) without increasing morbidity. The aim of the study was to compare the two most frequently used HHFNC devices in weaning from NCPAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>We performed a retrospective matched\u2010pair case\u2010control study of infants less than or equal to 28 GA born in a single tertiary neonatal center managed with Optiflow or Vapotherm after being weaned from NCPAP. Patients were matched for antenatal steroid doses, delivery mode, birth plurality, GA, birthweight, gender, surfactant doses, length of mechanical ventilation, and length of NCPAP. Outcome measures were duration of HHFNC, low\u2010flow nasal cannula, nasal bridge lesions, pneumothorax, bronchopulmonary dysplasia, postnatal steroids, necrotizing enterocolitis, sepsis, intraventricular hemorrhage, retinopathy of prematurity, length of stay, discharge weight, and mortality. Results were displayed as median (interquartile range) or ratio (percentage). Statistical analysis was performed using Mann\u2010Whitney U and <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>70 patients were recruited retrospectively. Thirty\u2010five infants were weaned from NCPAP to Optiflow and 35 infants to Vapotherm with gestational ages and birthweights of 27 GA (26\u201027) and 1010\u2009g (835\u20101165) and 27 GA (26\u201028) and 960\u2009g (788\u20101191), respectively. There was no statistically significant difference in any outcome measure. Infants managed with Vapotherm required a not statistically significant shorter length of time on HHFNC and low\u2010flow nasal cannula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Optiflow and Vapotherm seem to be equally effective and safe for weaning from NCPAP. However, infants weaned to Vapotherm appear to spend less time on non\u2010invasive respiratory support.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24936","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T16:00:54Z","timestamp":1593619254000},"page":"2624-2629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optiflow vs Vapotherm as extended weaning mode from nasal continuous positive airway pressure in preterm infants \u2264 28 weeks gestational age"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-8155","authenticated-orcid":false,"given":"J. Ramon","family":"Fernandez\u2010Alvarez","sequence":"first","affiliation":[{"name":"Department of Neonatology, Royal Sussex County Hospital Brighton and Sussex University Hospitals Trust  Brighton UK"},{"name":"Brighton and Sussex Medical School  Brighton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam","family":"Mahoney","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Hospitals Bristol and Weston NHS Foundation Trust  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Gandhi","sequence":"additional","affiliation":[{"name":"King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Rabe","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Royal Sussex County Hospital Brighton and Sussex University Hospitals Trust  Brighton UK"},{"name":"Brighton and Sussex Medical School  Brighton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(12)70022-1"},{"issue":"2","key":"e_1_2_8_3_1","first-page":"n23","article-title":"Nasal trauma in preterm infants receiving nasal continuous positive airway pressure","volume":"93","author":"Alsop EA","year":"2008","journal-title":"Arch Dis Child"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.179416"},{"issue":"2","key":"e_1_2_8_5_1","first-page":"CD006979","article-title":"Strategies for the withdrawal of nasal continuous positive airway pressure (NCPAP) in preterm infants","volume":"16","author":"Jardine LA","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_6_1","unstructured":"Optiflow\u2122. Fphcare.com.2020.Nasal high flow Fisher & Paykel Healthcare. [online] Available at:https:\/\/www.fphcare.com\/en-gb\/hospital\/infant-respiratory\/nasal-high-flow\/. [Accessed July 3 2020]."},{"key":"e_1_2_8_7_1","unstructured":"Vapotherm \u2010 Mask\u2010Free NIV.2020.Neonatal non-invasive respiratory support Vapotherm. [online] Available at:https:\/\/vapotherm.com\/neonatal-non-invasive-respiratory-support\/. [Accessed July 3 2020]."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ANC.0000317258.53330.18"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2010.01.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211825"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211530"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211647"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.5.1081"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211543"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2019.05.005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1606193"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462319000424"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.12.010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2116-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-015-0462-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/2008-7802.154922"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12693"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446063"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-111890"},{"key":"e_1_2_8_25_1","first-page":"1","article-title":"Chronic lung disease in preterm infants receiving various modes of non\u2010invasive ventilation at \u226430 weeks' postmenstrual age","volume":"26","author":"Leibel SL","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.38"},{"issue":"6","key":"e_1_2_8_27_1","first-page":"707","article-title":"AARC Clinical Practice Guideline: Selection of an oxygen delivery for neonatal and pediatric patients \u2010 2002 revision and update","volume":"47","author":"Myers TR","year":"2002","journal-title":"Respirat Care"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198404263101707"},{"key":"e_1_2_8_29_1","first-page":"428","volume-title":"Neurology of the Newborn","author":"Volpe JJ","year":"2001"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2007.12.004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2011-300133"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308991"},{"issue":"8","key":"e_1_2_8_33_1","first-page":"902","article-title":"An evaluation of 2 new devices for nasal high\u2010flow gas therapy","volume":"49","author":"Waugh JB","year":"2004","journal-title":"Respir Care"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05728"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181d9076d"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12277"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211543"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.24936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.24936","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T13:55:57Z","timestamp":1692626157000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.24936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/ppul.24936"],"URL":"https:\/\/doi.org\/10.1002\/ppul.24936","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"type":"print","value":"8755-6863"},{"type":"electronic","value":"1099-0496"}],"subject":[],"published":{"date-parts":[[2020,7,7]]},"assertion":[{"value":"2020-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}