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While ACS stimulates surfactant production in the fetal lung, the effects of ACS upon the subsequent growth and development of the lung are unclear. Follow\u2010up studies outside of the neonatal period have been primarily limited to spirometry, and most subjects evaluated were born prematurely. To our knowledge, no study has assessed both airway and parenchymal function in infants or adults following ACS exposure. We hypothesized that ACS impairs lung growth and performed infant pulmonary function testing, which included spirometry, alveolar volume (V<jats:sub>A<\/jats:sub>) and lung diffusion (D<jats:sub>L<\/jats:sub>). As a pilot study, we limited our assessment to infants whose mothers received ACS for threatened preterm labor, but then proceeded to full term delivery. This approach evaluated a more homogenous population and eliminated the confounding effects of preterm birth. We evaluated 36 full\u2010term infants between 4 to 12 months of age; 17 infants had ACS exposure and 19 infants had no ACS exposure. Infants exposed to ACS had a significantly lower forced vital capacity compared with non\u2010ACS exposed infants (250 vs 313\u2009mL; <jats:italic>P<\/jats:italic>\u2009=\u2009.0075). FEV<jats:sub>0.5<\/jats:sub> tended to be lower for the ACS exposed group (205 vs 237\u2009mL; <jats:italic>P<\/jats:italic>\u2009=\u2009.075). V<jats:sub>A<\/jats:sub> and D<jats:sub>L<\/jats:sub> did not differ between the two groups. These findings suggest that ACS may impair subsequent growth of the lung parenchyma.<\/jats:p>","DOI":"10.1002\/ppul.24941","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T07:55:25Z","timestamp":1593762925000},"page":"2630-2634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Antenatal corticosteriods decrease forced vital capacity in infants born fullterm"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9739-7355","authenticated-orcid":false,"given":"Anuja","family":"Bandyopadhyay","sequence":"first","affiliation":[{"name":"Division of Pulmonology, Departments of Pediatrics Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Slaven","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Evrard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Tiller","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Departments of Pediatrics Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3322-5903","authenticated-orcid":false,"given":"Robert S.","family":"Tepper","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Departments of Pediatrics Indiana University School of Medicine Indianapolis Indiana"},{"name":"Herman Wells Center for Pediatric Research Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"Cd004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","author":"Roberts D","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00151829-200403050-00004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200106000-00011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950050107"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2013.69"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.051763"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1070"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1183\/09031936.95.08061057","article-title":"Respiratory function measurements in infants: measurement conditions. 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