{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:16:35Z","timestamp":1790388995552,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cystic fibrosis is associated with significant morbidity and early mortality due to recurrent acute and chronic lung infections. The chronic use of multiple antibiotics without pathogen eradication increases the possibility of extensive drug resistance or even pan\u2010drug resistance (PDR). It is imperative that new or alternative treatment options be explored. We present a clinical case of a 10\u2010year\u2010old female cystic fibrosis patient, infected with a PDR <jats:italic>Achromobacter<\/jats:italic> spp. She was treated with cefiderocol, meropenem\/vaborbactam, and bacteriophage therapy (Ax2CJ45\u03d52) during two separate admissions in an attempt to clear her infection and restore baseline pulmonary function. The Centers for Disease Control and Prevention confirmed antibiotic susceptibilities, which showed resistance to both cefiderocol and meropenem\/vaborbactam. However, after using all three agents concomitantly during the second treatment course, our patient's pulmonary function improved dramatically, and the <jats:italic>Achromobacter<\/jats:italic> spp. could not be isolated from sputum samples obtained 8 and 16 weeks after completion of therapy. Overall, the treatment regimen consisting of cefiderocol, meropenem\/vaborbactam, and bacteriophage was safe and well\u2010tolerated in our patient.<\/jats:p>","DOI":"10.1002\/ppul.24945","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T16:09:41Z","timestamp":1594742981000},"page":"2990-2994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Combining bacteriophages with cefiderocol and meropenem\/vaborbactam to treat a pan\u2010drug resistant <i>Achromobacter<\/i> species infection in a pediatric cystic fibrosis patient"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0764-3397","authenticated-orcid":false,"given":"Andrew B.","family":"Gainey","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Division of Pediatric Infectious Diseases Prisma Health Children's Hospital \u2010 Midlands  Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Kathryn","family":"Burch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Infectious Diseases Prisma Health Children's Hospital \u2010 Midlands  Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Brownstein","sequence":"additional","affiliation":[{"name":"Adaptive Phage Therapeutics  Gaithersburg Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Pulmonology Prisma Health Children's Hospital \u2010 Midlands  Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Fackler","sequence":"additional","affiliation":[{"name":"Adaptive Phage Therapeutics  Gaithersburg Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bri'Anna","family":"Horne","sequence":"additional","affiliation":[{"name":"Adaptive Phage Therapeutics  Gaithersburg Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajit","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Genomics &amp; Bioinformatics Biological Defense Research Directorate, Naval Medical Research Center  Frederick Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany N.","family":"Bivens","sequence":"additional","affiliation":[{"name":"Department of Genomics &amp; Bioinformatics Biological Defense Research Directorate, Naval Medical Research Center  Frederick Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Malagon","sequence":"additional","affiliation":[{"name":"Department of Genomics &amp; Bioinformatics Biological Defense Research Directorate, Naval Medical Research Center  Frederick Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Division of Pediatric Infectious Diseases Prisma Health Children's Hospital \u2010 Midlands  Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30722-9"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01955-19"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02031-18"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","unstructured":"TsujiM NakamuraR KohiraN ItoA SatoT YamanoYS\u2010649266 a novel siderophore cephalosporin: in vitro combination effect of S\u2010649266 and other antibiotics against Gram\u2010negative bacteria. 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