{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:51:46Z","timestamp":1778917906757,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The use of tumor necrosis factor inhibitors (anti\u2010TNF) has a risk of activating latent tuberculosis infection (LTBI). This study was performed to investigate LTBI according to tuberculin skin test (TST) size and to determine the frequency of tuberculosis (TB) in bacillus Calmette\u2010Guerin (BCG)\u2010vaccinated children receiving anti\u2010TNF treatment for rheumatological disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The study consisted of 559 children. Information on demographics, anti\u2010TNF agents, TST size, and isoniazid (INH) prophylaxis was recorded. Patients (n\u2009=\u2009254) with TST size \u22655\u2009mm were divided into three groups according to TST size and INH prophylaxis: group 1, TST size 5 to 9\u2009mm and no INH prophylaxis; group 2, TST size 5 to 9\u2009mm with INH prophylaxis; and group 3, TST size \u226510\u2009mm with INH prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 559 patients comprised 314 (56.3%) females and 245 (43.6%) males; they had a mean age of 13.1\u2009\u00b1\u20094.1 years. The mean TST size in all patients was 4.2\u2009\u00b1\u20094.7\u2009mm. Group 1 consisted of 76 (29.9%) patients, group 2 consisted of 88 (34.6%) patients, and group 3 consisted of 90 (35.4%) patients. The mean TST sizes for the three groups were 6.8\u2009\u00b1\u20093.1\u2009mm, 7.2\u2009\u00b1\u20093.2\u2009mm, and 13.9\u2009\u00b1\u20092.8\u2009mm, respectively. New TB was diagnosed in only two (0.35%) patients. Both of them were in group 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A TST size of \u226510\u2009mm in BCG\u2010vaccinated children receiving anti\u2010TNF treatment may distinguish children at high risk for reactivation of LTBI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24963","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T17:22:19Z","timestamp":1595006539000},"page":"2689-2696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Determination of tuberculin skin test for isoniazid prophylaxis in BCG vaccinated children who are using anti\u2010TNF agents for rheumatologic diseases"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2879-8910","authenticated-orcid":false,"given":"Ayse Ayzit","family":"Kilinc","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology, Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Onal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berrak","family":"Oztosun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amra","family":"Adrovic","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sezgin","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Barut","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haluk","family":"Cokugras","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozgur","family":"Kasapcopur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.3.581"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2004.00710.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182833cbb"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4367-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24632"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/421494"},{"key":"e_1_2_6_8_1","unstructured":"World Health Organization.Global Tuberculosis Report 2017. Geneva Switzerland: World Health Organization. 2017."},{"key":"e_1_2_6_9_1","unstructured":"World Health Organization.Turkey\u2010 Tuberculosis Profile 2011. Turkey: World Health Organization. 2011."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70227-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2015.04.003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12726"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000434684"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-0867-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00028510"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5606\/ArchRheumatol.2020.7294"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.046797"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.01.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1133"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.supplement_3.ats600"},{"key":"e_1_2_6_21_1","unstructured":"Turkish Public Health Institution. Guideline for Tuberculosis in Patients Using Anti\u2010TNFa Treatment. Ankara Turkey: Ministry of Health. 2016."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.03.018"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-013-0417-0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1710-190"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-209397"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2015.02.039"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201811-784RL"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1138"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2226"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2019.1678582"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.5152\/ttd.2012.22"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.05.012"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-015-0054-4"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2030-8"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3714-6"},{"issue":"10","key":"e_1_2_6_36_1","first-page":"1127","article-title":"Tuberculosis in patients receiving anti\u2010TNF agents despite chemoprophylaxis","volume":"10","author":"Sichletidis L","year":"2006","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2017-5"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1086\/506935"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21734"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.118935"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1086\/505430"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.24963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.24963","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T13:55:10Z","timestamp":1692626110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.24963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,23]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/ppul.24963"],"URL":"https:\/\/doi.org\/10.1002\/ppul.24963","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,23]]},"assertion":[{"value":"2020-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}