{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T17:50:40Z","timestamp":1746208240801,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD092471","K12HD047349"],"award-info":[{"award-number":["HD092471","K12HD047349"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL0114484","HL086622","HL086649","HL095410","HL140026"],"award-info":[{"award-number":["HL0114484","HL086622","HL086649","HL095410","HL140026"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims and Objectives<\/jats:title><jats:p>Alveolar epithelial injury is a key determinant of acute respiratory failure (ARF) severity. Plasma surfactant protein D (SP\u2010D), a biomarker of alveolar epithelial injury, is lower in obese adults with ARF compared to their lean peers. We aimed to determine if children with ARF have similar variance in plasma SP\u2010D associated with their weight status on admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma SP\u2010D was measured on days 0, 1, or 2 in children (1\u201018 years) with ARF enrolled in the genetic variation and biomarkers in children with acute lung injury and <jats:italic>RESTORE<\/jats:italic> studies. Weight classification (underweight, normal, overweight, and obese) was based on body mass index or weight\u2010for\u2010height z\u2010scores. Associations between weight group and SP\u2010D on each day were tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inclusion criteria were met in 212 subjects, 24% were obese. There were no differences among weight groups in SP\u2010D levels on days 0 and 1. However, on day 2, there was a statistically significant linear trend for lower SP\u2010D levels as weight increased in both the univariate analysis (<jats:italic>P<\/jats:italic>\u2009=\u2009.02) and when adjusting for age, ethnicity, and diagnosis of pediatric acute respiratory distress syndrome (<jats:italic>P<\/jats:italic>\u2009=\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obesity was associated with lower plasma SP\u2010D levels on day 2 of ARF. This finding may be explained by altered ARF pathogenesis in obese individuals or a reduced incidence of ventilator\u2010induced lung injury.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24990","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T18:30:47Z","timestamp":1596047447000},"page":"2730-2736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1375-6240","authenticated-orcid":false,"given":"Shan L.","family":"Ward","sequence":"first","affiliation":[{"name":"Division of Critical Care, Department of Pediatrics UCSF Benioff Children's Hospitals San Francisco and Oakland California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary K.","family":"Dahmer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Department of Pediatrics University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3467-7987","authenticated-orcid":false,"given":"Heidi M.","family":"Weeks","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Michigan School of Public Health Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Sapru","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics Mattel Children's Hospital at UCLA Medical Center Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Quasney","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Department of Pediatrics University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha A. 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