{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T17:50:40Z","timestamp":1746208240694,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774164"],"award-info":[{"award-number":["81774164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV2) is spreading all over the world and poses a great threat to humans. This study aimed to systematically review the current situation and public health burden associated with children infected with SARS\u2010CoV2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched four electronic databases without language limitations. The pooled proportion or odds ratio (OR) and 95% CI confidence interval (CI) were calculated for each analysis to explore the prevalence of asymptomatic infection and coinfection, as well as to assess the sex of SARS\u2010CoV\u20102\u2010infected children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We obtained data from 14 eligible studies with 410 patients for the meta\u2010analysis. The pooled proportion of asymptomatic infection was 40.45% (95% CI, 24.04\u201056.85), while coinfection was 10.14% (95% CI, 3.97\u201016.30), of which <jats:italic>Mycoplasma pneumonia<\/jats:italic> (50%; 95% CI, 28.24\u201071.76) and influenza virus or parainfluenza virus (22.76%; 95% CI, 4.76\u201040.77) were the most common pathogens. Both male and female children were susceptible to SARS\u2010CoV2 infection. And the pooled proportion of family clustering infection was 83.63% (95% CI, 77.54\u201089.72).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high proportion of asymptomatic infections occurs in children infected with SARS\u2010CoV2, who are also susceptible to coinfection regardless of sex. These data affirm the increasing public health burden arising from infected children regarding the causation of asymptomatic infection or misdiagnosis and as a significant contributor to virus spread. The public should pay more attention to children during epidemics and conduct multimethod detection to further effectively identify infected children and control the source of infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25008","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T20:43:20Z","timestamp":1596660200000},"page":"3487-3496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An increasing public health burden arising from children infected with SARS\u2010CoV2: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-7867","authenticated-orcid":false,"given":"Baojia","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, School of Basic Medical Sciences Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Basic Medical Sciences Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuixiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Nursing Department of the Fifth Affiliated Hospital of Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"79","article-title":"Notes from the field: an outbreak of NCIP (2019\u2010nCoV) infection in China\u2010Wuhan, Hubei Province, 2019\u20132020","volume":"2","author":"The 2019\u2010nCoV Outbreak Joint Field Epidemiology Investigation Team","year":"2020","journal-title":"China CDC Weekly"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.46234\/ccdcw2020.017"},{"key":"e_1_2_7_4_1","unstructured":"Dadax.COVID\u201019 coronavirus outbreak Available at:https:\/\/www.worldometers.info\/coronavirus"},{"key":"e_1_2_7_5_1","unstructured":"World Health Organization.Novel coronavirus(2019\u2010nCoV): situation report\u201484.https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200413-sitrep-84-covid-19.pdf?sfvrsn=44f511ab_2. 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