{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:44:08Z","timestamp":1790675048867,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the lung functions with impulse oscillometry (IOS) and spirometry in children with type 1 diabetes mellitus (T1DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010one children with T1DM, and sex\u2010 and age\u2010matched 53 healthy control (HC) subjects were included in this study. Demographic, clinical, and laboratory characteristics of the subjects were recorded and their pulmonary functions were analyzed by IOS and spirometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In IOS, zR5, zR10, and zR20 levels were higher in children with T1DM compared with HCs (<jats:italic>P<\/jats:italic>\u2009=\u2009.019, <jats:italic>P<\/jats:italic>\u2009=\u2009.017, and <jats:italic>P<\/jats:italic>\u2009=\u2009.002, respectively). In spirometry, zFEF75 and zFEF25\u201075 were lower in children with T1DM compared with HCs (<jats:italic>P<\/jats:italic>\u2009=\u2009.025, <jats:italic>P<\/jats:italic>\u2009=\u2009.001, respectively). In IOS, zR5\u201020 (<jats:italic>P<\/jats:italic>\u2009=\u2009.008, <jats:italic>P<\/jats:italic>\u2009=\u2009.005, respectively) and zAX (<jats:italic>P<\/jats:italic>\u2009=\u2009.013, <jats:italic>P<\/jats:italic>\u2009=\u2009.009, respectively) were significantly lower in good\u2010controlled group compared with moderate\u2010 and poor\u2010controlled group. In spirometry, zFEF25\u201075 was significantly higher in good\u2010controlled group compared with moderate\u2010 and poor\u2010controlled group (<jats:italic>P<\/jats:italic>\u2009=\u2009.005, <jats:italic>P<\/jats:italic>\u2009=\u2009.009, respectively). HbA1c was positively correlated with zR5\u201020 value (<jats:italic>r<\/jats:italic>\u2009=\u2009.339; <jats:italic>P<\/jats:italic>\u2009=\u2009.017) in male children with T1DM. The duration of the disease was positively correlated with zR5\u201020 (<jats:italic>r<\/jats:italic>\u2009=\u2009.290; <jats:italic>P<\/jats:italic>\u2009=\u2009.043) and zFres (<jats:italic>r<\/jats:italic>\u2009=\u2009.358; <jats:italic>P<\/jats:italic>\u2009=\u2009.010). According to the receiver operating characteristic curve analysis to estimate optimal cut\u2010offs to discriminate good control level of T1DM (HbA1c\u2009&lt;\u20097%), a zR5\u201020\u2009\u2264\u20092.28 demonstrated a 75.0% sensitivity and 82.9% specificity, with an area under the curve of 0.805 ([confidence interval, 0.615\u20100.995]; <jats:italic>P<\/jats:italic>\u2009=\u2009.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed subclinical impairment of lung functions which is associated with disease duration and the degree of metabolic control in children with T1DM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25019","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T16:04:39Z","timestamp":1596902679000},"page":"3517-3524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessment of pulmonary function by impulse oscillometry and spirometry in children with type 1 diabetes mellitus"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0673-3403","authenticated-orcid":false,"given":"Ay\u015fe","family":"An\u0131k","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine Ayd\u0131n Adnan Menderes University Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-7872","authenticated-orcid":false,"given":"Ahmet","family":"An\u0131k","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Division of Endocrinology Ayd\u0131n Adnan Menderes University Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0288-608X","authenticated-orcid":false,"given":"P\u0131nar","family":"Uysal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Division of Allergy and Immunology Ayd\u0131n Adnan Menderes University Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00003.2010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399812666151016101622"},{"issue":"11","key":"e_1_2_7_4_1","first-page":"1728","article-title":"Lung function in type 1 Saudi diabetic patients","volume":"26","author":"Meo SA","year":"2005","journal-title":"Saudi Med J"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(94)90004-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2016.0627"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"163","article-title":"Pulmonary function in children with type 1 diabetes mellitus","volume":"28","author":"Martin\u2010Frias M","year":"2015","journal-title":"J Pediatr Endocrinol Metab"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018815580514"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(93)90066-E"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10399"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","unstructured":"Standardization of Spirometry 1994 Update. 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