{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:33Z","timestamp":1770681633831,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bronchiectasis (BE) is defined as a permanent, irreversible dilation of the bronchial tree. In the pediatric population, this disease process is most commonly associated with patients with cystic fibrosis (CF). However, BE unrelated to CF is increasingly noted as a cause of chronic respiratory related morbidity worldwide. Chronic inflammation and recurrent infection result in cellular cascades that lead to irreversible structural changes of the airways. When these architectural changes occur, they confer extensive risks to morbidity usually due to continued infections. In the adult population, BE has been associated with chronic obstructive pulmonary disease, which is mainly caused by cigarette smoking. In this report, the authors reviewed various cases of BE in the pediatric population at our institution. After a comprehensive case by case review, we compiled details of three cases of newly diagnosed BE where the most likely inciting factor was the electronic cigarette use. Common features of the three cases included at least a year of e\u2010cigarette use with conjunction of tetrahydrocannabinol and radiologic findings of BE, ground glass opacities, and nodule formation.<\/jats:p>","DOI":"10.1002\/ppul.25062","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T16:37:36Z","timestamp":1600965456000},"page":"3443-3449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bronchiectasis associated with electronic cigarette use: A case series"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-4058","authenticated-orcid":false,"given":"Eric S.","family":"Mull","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4938-9075","authenticated-orcid":false,"given":"Richard","family":"Shell","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Nationwide Children's Hospital Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Ohio State University Columbus Ohio USA"},{"name":"Division of Radiology Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Holtzlander","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Nationwide Children's Hospital Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31554-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2015140214"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0016-2018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l2219"},{"key":"e_1_2_9_6_1","unstructured":"Centers for Disease Control and Prevention.\u00a0Outbreak of lung injury associated with the use of e\u2010cigarette or vaping products. 2020. Accessed April 17 2020."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30415-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1164\/rccm.201903-0615OC","article-title":"Chronic E\u2010cigarette use increases neutrophil elastase and matrix metalloprotease levels in the lung","volume":"200","author":"Ghosh A","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0776"},{"key":"e_1_2_9_10_1","first-page":"5","article-title":"Bronchiectasis: a retrospective study of clinical and aetiological investigations in general respiratory disease department","volume":"21","author":"Amorim A","year":"2015","journal-title":"Rev Port Pneumol"},{"key":"e_1_2_9_11_1","article-title":"Aetiology of bronchiectasis in adults: a aystematic literature review","author":"Gao YH","year":"2016","journal-title":"Respiratory"},{"key":"e_1_2_9_12_1","first-page":"1","article-title":"Paired CT measures of emphysema and small airway disease and lung function and exercise capacity in smokers with radiologic bronchiectasis","author":"Martinez CH","year":"2020","journal-title":"Acad Radiol"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T09:29:55Z","timestamp":1693733395000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,21]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/ppul.25062"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25062","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,21]]},"assertion":[{"value":"2020-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}