{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:10:11Z","timestamp":1781683811549,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Childhood cancer survivors (CSs) might face an increased lifelong risk of lung function impairment. The lung clearance index (LCI) has been described as being more sensitive than spirometry in the early stages of some lung diseases. The aim of this study was to evaluate this index in a cohort of patients with a history of childhood cancer for the first time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We evaluated 57 off\u2010treatment CSs aged 0\u201318\u2009years old and 50 healthy controls (HCs). We used the multiple\u2010breath washout\u00a0method to study LCI and spirometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CSs did not show any differences from the controls in ventilation homogeneity (LCI 6.78\u2009\u00b1\u20091.35 vs. 6.32\u2009\u00b1\u20090.44;\u00a0<jats:italic>p<\/jats:italic>: not significant [ns]) or lung function (FEV1 99.9\u2009\u00b1\u200911.3% vs. 103.0\u2009\u00b1\u20095.9% of predicted;\u00a0<jats:italic>p<\/jats:italic>: ns; FVC 98.2\u2009\u00b1\u200910.3% vs. 101.1\u2009\u00b1\u20093.3% of predicted). LCI significantly correlated with the number of years since the last chemotherapy (<jats:italic>r<\/jats:italic>\u2009=\u2009.35, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study describes the trend of LCI in a cohort of CSs and compares it with the results obtained from HCs. The results show that patients maintain both good values of respiratory function and good homogeneity of ventilation during childhood. Moreover, as LCI increases and worsens as the years pass after the end of the treatment could identify the tendency toward\u00a0pulmonary fibrosis, which is typical of adult CSs, at an earlier time than spirometry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25071","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T16:37:36Z","timestamp":1600965456000},"page":"3450-3456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Lung clearance index: A new measure of late lung complications of cancer therapy in children"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4291-0195","authenticated-orcid":false,"given":"Giuseppe F.","family":"Parisi","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology Unit, Department of Clinical and Experimental Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Cannata","sequence":"additional","affiliation":[{"name":"Pediatric Hemato\u2010Oncology Unit, Department of Clinical and Experimental Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-3083","authenticated-orcid":false,"given":"Sara","family":"Manti","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Department of Clinical and Experimental Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5036-2374","authenticated-orcid":false,"given":"Maria","family":"Papale","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Department of Clinical and Experimental Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariaclaudia","family":"Meli","sequence":"additional","affiliation":[{"name":"Pediatric Hemato\u2010Oncology Unit, Department of Clinical and Experimental Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-7473","authenticated-orcid":false,"given":"Giovanna","family":"Russo","sequence":"additional","affiliation":[{"name":"Pediatric Hemato\u2010Oncology Unit, Department of Clinical and Experimental Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4509-3066","authenticated-orcid":false,"given":"Andrea","family":"Di Cataldo","sequence":"additional","affiliation":[{"name":"Pediatric Hemato\u2010Oncology Unit, Department of Clinical and Experimental Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2642-6400","authenticated-orcid":false,"given":"Salvatore","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Department of Clinical and Experimental Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"63","article-title":"Pulmonary complications of childhood cancer treatment","volume":"17","author":"Verluys AB","year":"2017","journal-title":"Paediatr Respir Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12010116"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05223"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.032"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10297"},{"key":"e_1_2_9_7_1","first-page":"147","article-title":"Inert gas washout: background and application in various lung diseases","volume":"16","author":"Usemann J","year":"2017","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200407-895OC"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.1.2107093"},{"issue":"1","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1172\/JCI102575","article-title":"Lung function studies. 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