{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:28:42Z","timestamp":1765704522573,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF2020R1F1A1076452"],"award-info":[{"award-number":["NRF2020R1F1A1076452"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To determine the response of airway mechanics and the changes in asthma symptoms to stepping down of leukotriene receptor antagonist (LTRA) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty children (mean age: 7.1 years) with mild, well\u2010controlled, and persistent asthma who took LTRA as maintenance treatment were randomized into a double\u2010blind, placebo\u2010controlled, cross\u2010over study. Each group received an LTRA (montelukast) or placebo daily for 2 weeks, followed by a 1\u2010week washout period, and then the alternate treatment for 2 weeks. Spirometry and impulse oscillation system (IOS) measurements before and after four puffs of salbutamol inhalation, fractional exhaled nitric oxide (FeNO), and the childhood asthma control test (C\u2010ACT) were evaluated at baseline, the end of placebo treatment, and the end of LTRA treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Changes of FEV<jats:sub>1<\/jats:sub>\/FVC (<jats:italic>p<\/jats:italic>\u2009=\u2009.113) and FEV<jats:sub>1<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u2009.109) from baseline to posttreatment did not differ significantly between the placebo and montelukast groups. In the placebo group, prebronchodilator (pre\u2010) FEV<jats:sub>1<\/jats:sub>\/FVC was decreased (83% vs. 86%) and bronchodilator response (BDR) in FEV<jats:sub>1<\/jats:sub> was diminished (10.7% vs. 6.4%) at posttreatment compared with baseline. However, the montelukast group had no significant changes in pre\u2010FEV<jats:sub>1<\/jats:sub>\/FVC (<jats:italic>p<\/jats:italic>\u2009=\u2009.865) and BDR in FEV<jats:sub>1<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u2009.461). In addition, compared with the montelukast group, the placebo group showed no significant changes in Rrs5 (total airway resistance), Rrs5\u201320 (peripheral airway resistance), FeNO, and symptoms by the C\u2010ACT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In children with well\u2010controlled mild persistent asthma, changes in spirometry, IOS, FeNO, and C\u2010ACT results did not differ between the placebo and montelukast groups within 2 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25085","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T16:29:10Z","timestamp":1600878550000},"page":"3279-3286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Airway mechanics after withdrawal of a leukotriene receptor antagonist in children with mild persistent asthma: Double\u2010blind, randomized, cross\u2010over 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-5729","authenticated-orcid":false,"given":"Eun Kyo","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kangnam Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-5208","authenticated-orcid":false,"given":"Seung Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Data Science Sejong University College of Software Convergence  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1253-6075","authenticated-orcid":false,"given":"Mi\u2010Ae","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, CHA Bundang Medical Center CHA University School of Medicine  Seongnam Republic of 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