{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:33:59Z","timestamp":1776134039620,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) is a global health problem that can result in serious complications. The aim of this study was to investigate the prevalence and clinical importance of vitamin D deficiency in children with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>This study includes 40 patients who were diagnosed to have COVID\u201019 and hospitalized with the real\u2010time reverse transcription polymerase chain reaction method, 45 healthy matched control subjects with vitamin D levels. The age of admission, clinical and laboratory data, and 25\u2010hydroxycholecalciferol (25\u2010OHD) levels were recorded. Those with vitamin D levels which are below 20\u2009ng\/ml were determined as Group 1 and those with \u226520\u2009ng\/ml as Group 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with COVID\u201019 had significantly lower vitamin D levels 13.14\u2009\u03bcg\/L (4.19\u201369.28) than did the controls 34.81 (3.8\u201377.42) \u03bcg\/L (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Patients with COVID\u201019 also had significantly lower serum phosphorus (4.09\u2009\u00b1\u20090.73 vs. 5.06\u2009\u00b1\u20090.93 vs. (U\/L) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001)) values compared with the controls. The symptom of fever was significantly higher in COVID\u2010 19 patients who had deficient and insufficient vitamin D levels than in patients who had sufficient vitamin D levels (<jats:italic>p<\/jats:italic>\u2009=\u2009.038). There was a negative correlation found between fever symptom and vitamin D level (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.358, <jats:italic>p<\/jats:italic>\u2009=\u2009.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first to evaluate vitamin D levels and its relationship with clinical findings in pediatric patients with COVID\u201019. Our results suggest that vitamin D values may be associated with the occurrence and management of the COVID\u201019 disease by modulating the immunological mechanism to the virus in the pediatric population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25106","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T13:59:53Z","timestamp":1601906393000},"page":"3595-3601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Is vitamin D deficiency a risk factor for COVID\u201019 in children?"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-0501","authenticated-orcid":false,"given":"Kamil","family":"Y\u0131lmaz","sequence":"first","affiliation":[{"name":"Department of Pediatric Dicle University School of Medicine  Diyarbakir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velat","family":"\u015een","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Dicle University School of Medicine  Diyarbakir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12040988"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2020.110835"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Rheumatologists' perspective on coronavirus disease 19 (COVID\u201019) and potential therapeutic targets","author":"Misra DP","year":"2020","journal-title":"Clin Rheumatol"},{"key":"e_1_2_8_5_1","article-title":"The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID\u201019)\u2014China, 2020","author":"Zhang Y","year":"2020","journal-title":"Chinese J 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