{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:35:31Z","timestamp":1792096531105,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The autonomic nervous system (ANS) plays an important role in modulating bronchial smooth muscle contractility, which is altered in cystic fibrosis (CF). A convenient approach to probe ANS regulation is the quantitative analysis of heart rate variability (HRV). The purpose of this study was to evaluate ANS regulation in children with CF and to investigate the influence of colonization by <jats:italic>Pseudonomas aeruginosa<\/jats:italic> via assessment of HRV in colonized CF (CCF) children and noncolonized CF (NCCF) children. Sixteen children with CF (7 CCF and 9 NCCF) and seven healthy age\u2010matched control children were enrolled in the study. Heart rate was recorded for 10\u2009min at rest in the supine and standing positions and HRV analysis was carried out using autoregressive spectral analysis. The CCF group was characterized by lower forced expiratory volume than NCCF, indicating an impairment of respiratory function. The HRV parameters further confirmed the possible sympathetic overactivity in CCF. Children with CF exhibited hyperactivity of the sympathetic nervous system. In particular, the CCF group presented a greater impairment of ANS modulation. Both CCF and NCCF children showed lower supine vagal activation in the HRV indices related to sympathetic activation and reduction of indices indicating vagal activity with the postural change from supine to standing when compared to the NCCF group.<\/jats:p>","DOI":"10.1002\/ppul.25147","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T10:37:55Z","timestamp":1604054275000},"page":"120-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of autonomic modulation of lung function and heart rate in children with cystic fibrosis"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5765-7228","authenticated-orcid":false,"given":"Etiene F.","family":"Teixeira de Carvalho","sequence":"first","affiliation":[{"name":"Departament of Master's and Doctoral Programs in Rehabilitation Sciences Nove de Julho University S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1472-837X","authenticated-orcid":false,"given":"Federico","family":"Aletti","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California San Diego La Jolla California USA"},{"name":"Dipartimento di Elettronica Informazione e Bioingegneria, Politecnico di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8566-7976","authenticated-orcid":false,"given":"Ivan P.","family":"Costa","sequence":"additional","affiliation":[{"name":"Departament of Master's and Doctoral Programs in Rehabilitation Sciences Nove de Julho University S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0636-6041","authenticated-orcid":false,"given":"Evelim L. F. D.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia P.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Departament of Master's and Doctoral Programs in Rehabilitation Sciences Nove de Julho University S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neiva","family":"Damasceno","sequence":"additional","affiliation":[{"name":"Departament Pediatric Pulmonology \u2010 Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia H.","family":"Muramatu","sequence":"additional","affiliation":[{"name":"Departament Pediatric Pulmonology \u2010 Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9623-8704","authenticated-orcid":false,"given":"Vera L.","family":"dos Santos Alves","sequence":"additional","affiliation":[{"name":"Departament Pediatric Pulmonology \u2010 Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7371-3624","authenticated-orcid":false,"given":"Manuela","family":"Ferrario","sequence":"additional","affiliation":[{"name":"Dipartimento di Elettronica Informazione e Bioingegneria, Politecnico di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence P.","family":"Cahalin","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Miller School of Medicine University of Miami Ponce de Leon Boulevard, 5th Floor \u2013 Coral Gable Miami FL 5915 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0110-7710","authenticated-orcid":false,"given":"Luciana M. M.","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Departament of Master's and Doctoral Programs in Rehabilitation Sciences Nove de Julho University S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70092-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.489"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.02.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1606.100063"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2007.12.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20517"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22917"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01390-2015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e3180332d1c"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132004000100004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83478-X"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1979.sp012814"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00313.2006"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6166045"},{"issue":"4","key":"e_1_2_9_16_1","first-page":"H867","article-title":"Hemodynamic regulation: investigation by spectral analysis","volume":"249","author":"Akselrod S","year":"1985","journal-title":"Am J Physiol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.59.2.178"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014868"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2252"},{"issue":"2","key":"e_1_2_9_20_1","first-page":"113","article-title":"Study of heart rate autonomic modulation in patients with asthma disease","volume":"51","author":"Souza VF","year":"2010","journal-title":"Med Sci Tech"},{"issue":"1","key":"e_1_2_9_21_1","first-page":"7","article-title":"Avalia\u00e7\u00e3o da modula\u00e7\u00e3o auton\u00f4mica da frequ\u00eancia card\u00edaca nas posturas supina e sentada em homens jovens sedent\u00e1rios","volume":"12","author":"Zuttin RS","year":"2008","journal-title":"Rev Bra Fisioter"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151464"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.76.s2.05"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.03.002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1634ST"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-75-5-819_2"},{"key":"e_1_2_9_27_1","unstructured":"WHO Expert Committee on Physical Status: the use and interpretation of anthropometry (1993: Geneva Switzerland) & World Health Organization. (1995). Physical status: the use of and interpretation of anthropometry report of a WHO expert committee. World Health Organization."},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1629"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.043497"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.4.1776"},{"issue":"3","key":"e_1_2_9_31_1","first-page":"S155","article-title":"Press\u00f5es respirat\u00f3rias est\u00e1ticas m\u00e1ximas","volume":"28","author":"Souza RB","year":"2002","journal-title":"J Bras Pneumol"},{"issue":"5","key":"e_1_2_9_32_1","first-page":"419","article-title":"Heart rate variability at rest and after the 6\u2010minute walk test (6MWT) in children with cystic fibrosis","volume":"17","author":"Flor\u00eancio R","year":"2013","journal-title":"Braz J Phys Ther"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2010007500101"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322010000800008"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-35552007000100007"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2009.02039.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132004000100004"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/prrv.2001.0167"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23242"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62472-6"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.12659\/MST.883863"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21167"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.5.1432"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.04.015"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physio.2017.07.004"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25147","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T08:13:30Z","timestamp":1693642410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,6]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/ppul.25147"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25147","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,6]]},"assertion":[{"value":"2020-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}