{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:15:25Z","timestamp":1790673325863,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lung transplantation is a treatment option for selected children with end\u2010stage lung disease and pulmonary vascular disorders. Overall, pulmonary hypertension (PH) is the second most frequent indication for infants and children requiring lung transplants. In pediatric PH patients, timing for listing remains a difficult decision due to patient heterogeneity and varying allocation policies across different countries. Furthermore, perioperative management can be challenging, making interdisciplinary collaboration among surgical, anesthesiology, critical care, and lung transplant teams essential. Because pediatric PH patients typically have preserved cardiac index and exercise tolerance even with advanced disease, they should be referred early even if they do not meet the criteria for listing of primarily adults by International Society for Heart and Lung Transplantation (ISHLT) published in 2015: New York Heart Association (NYHA) functional class III or IV without improvement, cardiac index\u2009&lt;\u20092\u2009L\/min\/m<jats:sup>2<\/jats:sup>, mean right atrial pressure of &gt;15\u2009mmHg. Bridging strategies with extracorporeal support should be determined at the time of listing in anticipation of possible clinical deterioration. Bilateral lung transplantation using cardiopulmonary bypass to provide hemodynamic stability is nowadays the standard surgical approach in pediatric centers. The immediate post\u2010transplant period is characterized by dramatic changes in the right ventricle (RV) and and left ventricle (LV) anatomy and physiology, which can be life\u2010threatening. Induction, immunosuppression, prophylaxis, and surveillance are not different from patients without PH. Overall, outcomes in pediatric lung and heart\u2013lung transplant patients for PH are not different from those children undergoing transplantation for other indications. In fact, long\u2010term survival is superior in children with idiopathic PH compared to other diseases, providing most recipients with improved quality of life.<\/jats:p>","DOI":"10.1002\/ppul.25154","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T21:29:21Z","timestamp":1605821361000},"page":"587-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Lung transplantation as an intervention for pediatric pulmonary hypertension"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5696-7112","authenticated-orcid":false,"given":"Ernestina","family":"Melicoff","sequence":"first","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-6052","authenticated-orcid":false,"suffix":"\u00a0Jr","given":"Don","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Benden","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000630"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2002.00217.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.07.84"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-015-9765-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2016.1168298"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.07.021"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.014"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05304"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01276.x"},{"key":"e_1_2_9_11_1","volume-title":"Current Concepts in Pediatric Critical Care 2015","author":"Coleman R","year":"2015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.10.087"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"44","article-title":"Diagnosis, evaluation and treatment of pulmonary arterial hypertension in children","volume":"5","author":"Frank BS","year":"2018","journal-title":"Children (Basel)"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.06.022"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201109-1599OC"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12152"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.04.012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.08.017"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02549.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.08.078"},{"issue":"8","key":"e_1_2_9_21_1","first-page":"1070","article-title":"Bridge to lung transplantation and rescue post\u2010transplant: the expanding role of extracorporeal membrane oxygenation","volume":"6","author":"Gulack BC","year":"2014","journal-title":"J Thorac Dis"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.04.020"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.08.055"},{"key":"e_1_2_9_24_1","unstructured":"United Network for Organ Sharing.http:\/\/www.unos.org. 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