{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:08:50Z","timestamp":1790255330438,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23\u2010HL136688"],"award-info":[{"award-number":["K23\u2010HL136688"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>High frequency percussive ventilation (HFPV) is used in acute respiratory failure, but is poorly described in pediatrics. We aimed to describe the clinical characteristics, ventilator settings, and outcomes of a large pediatric cohort, and to determine predictors of who would benefit from HFPV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Gas exchange 2\u2009h after HFPV initiation predicts success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Single center retrospective cohort study testing association between gas exchange 2\u2009h after HFPV initiation with success, defined a priori.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Intubated children on HFPV for \u22652\u2009h from 2012 to 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We described indications, ventilator settings, and gas exchange immediately before, 2\u2009h after, and at termination of HFPV. Univariate and multivariate regression tested association of oxygenation and ventilation after HFPV initiation with success. Areas under the receiver operating characteristic (AUROC) curve and adjusted odds ratios (aORs) were computed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We performed 237 courses of HFPV in 193 children (22% non\u2010survivors), of which 162 (68%) were successful. In univariate analysis, pH (AUROC, 0.65) and PCO\n                      <jats:sub>2<\/jats:sub>\n                      (AUROC, 0.66) 2\u2009h after HFPV predicted success. In multivariate analysis, pH (aOR: 1.67 per 1\n                      <jats:italic>SD<\/jats:italic>\n                      ; 95% confidence interval [CI]: 1.19\u20132.35), PCO\n                      <jats:sub>2<\/jats:sub>\n                      (aOR: 0.49 per 1\n                      <jats:italic>SD<\/jats:italic>\n                      ; 95% CI: 0.31\u20130.79), and oxygenation index (aOR: 0.66 per 1\n                      <jats:italic>SD<\/jats:italic>\n                      ; 95% CI: 0.44\u20130.97) 2\u2009h after HFPV initiation were associated with success.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We describe the largest cohort of HFPV to date, with detailed description of indications and settings. Gas exchange after 2\u2009h of HFPV was independently associated with success.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.25191","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T09:23:28Z","timestamp":1606814608000},"page":"502-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["High frequency percussive ventilation in pediatric acute respiratory failure"],"prefix":"10.1002","volume":"56","author":[{"given":"Andrew D.","family":"Butler","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Children's Hospital of Philadelphia and University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Dominick","sequence":"additional","affiliation":[{"name":"Department of Respiratory Therapy Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-217X","authenticated-orcid":false,"given":"Nadir","family":"Yehya","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Children's Hospital of Philadelphia and University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.01.021"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"12","article-title":"Use of high\u2010frequency ventilation in the pediatric intensive care unit","volume":"5","author":"Tawfik DS","year":"2016","journal-title":"J Pediatr Intensive 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