{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:10:51Z","timestamp":1790255451851,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inhomogeneous lung ventilation and pulmonary air leaks are common adverse effects of mechanical ventilation in preterm infants suffering from respiratory distress syndrome. We hypothesized that shortening of inspiratory times can improve the homogeneity of lung aeration. We assumed that ultrashort inspiratory times lead to a full build\u2010up of pressure in regions with low compliance while maintaining incomplete filling of regions with high compliance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We connected a two\u2010compartment model of the lung with different compliances of the two compartments to a neonatal ventilator. Pressures and flow rates were measured separately for each compartment at inspiratory times ranging from 0.1 to 0.8\u2009s and various combinations of tidal volumes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An inspiratory time of 0.8\u2009s resulted in near total pressure equalization between the airway pressure and the two compartments, as 97% of the maximum applied peak pressure was reached in the low compliance compartment and 95% in the high compliance compartment. The distribution of the tidal volume was proportional to the compartment compliance. Ultrashort inspiratory times lowered the peak pressure and tidal volume in the high compliance compartment but maintained higher pressure and volume in the low compliance compartment. An inspiratory time of 0.2\u2009s resulted in a peak pressure of 80% of peak airway pressure in the low compliance compartment and in 61% of peak airway pressure in the high compliance compartment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ventilation with ultrashort inspiratory times may improve homogeneity of air distribution in inhomogeneous lungs of ventilated preterm or term infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.25193","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T08:58:50Z","timestamp":1606899530000},"page":"418-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ultrashort inspiratory times homogenize ventilation distribution in an inhomogeneous two\u2010compartment model of the neonatal lung"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9231-6683","authenticated-orcid":false,"given":"Jana","family":"Baumgartner","sequence":"first","affiliation":[{"name":"Division of Neonatology and Pediatric Intensive Care Medicine, Center for Pediatrics and Adolescent Medicine, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-3866","authenticated-orcid":false,"given":"Daniel","family":"Klotz","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Pediatric Intensive Care Medicine, Center for Pediatrics and Adolescent Medicine, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendryk","family":"Schneider","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Pediatric Intensive Care Medicine, Center for Pediatrics and Adolescent Medicine, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schumann","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1303-3699","authenticated-orcid":false,"given":"Hans","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Pediatric Intensive Care Medicine, Center for Pediatrics and Adolescent Medicine, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000375361"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9906103"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3283423e6b"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2006.12.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-4200-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201704-338OT"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.6.834"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1980.04490010031011"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01954127"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80604-X"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","unstructured":"Multicentre randomised controlled trial of high against low frequency positive pressure ventilation. Oxford Region Controlled Trial of Artificial Ventilation OCTAVE Study Group.Arch Dis Child1991;66(7 Spec No):770\u2013775.","DOI":"10.1136\/adc.66.7_Spec_No.770"},{"key":"e_1_2_9_13_1","first-page":"294","volume-title":"Fetoneonatale Lunge","author":"Hentschel R","year":"2017"},{"key":"e_1_2_9_14_1","unstructured":"vanKaamAH De LucaD HentschelR et al.Modes and strategies for providing conventional mechanical ventilation in neonates.Pediatr Res2019Nov 30 epub ahead of print."},{"key":"e_1_2_9_15_1","article-title":"Long versus short inspiratory times in neonates receiving mechanical ventilation","volume":"4","author":"Kamlin COF","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9604014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.5.1194"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.3.730"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-1006OC"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2017.06.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000456.pub4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.71.3.F161"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2016.08.008"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25193","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:54:53Z","timestamp":1790254493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,14]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/ppul.25193"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25193","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,14]]},"assertion":[{"value":"2020-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}