{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:58:59Z","timestamp":1776952739157,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is limited data on management strategies for chronic pulmonary hypertension (cPH) in chronic lung disease (CLD) of prematurity. Our objective was to evaluate clinical outcomes following a standardized policy, wherein only cPH with right\u2010ventricular (RV) dilatation was treated and diuretics were employed as first\u2010line therapy; cPH without RV\u2010dilatation was managed expectantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this retrospective cohort study, all infants with CLD were categorized as \u201cCLD\u2010only\u201d or \u201cCLD\u2013cPH,\u201d using echocardiography at \u226536 weeks postmenstrual age. Intergroup comparison was performed. Regression analysis examined the association between cPH and primary outcome of death or disability at 18\u201324 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 128 CLD infants, 48 (38%) had cPH, of which 29 (60%) received diuretics. Symptomatic improvement within 1\u2010week was recorded in 90%. Although CLD\u2013cPH had worse in\u2010hospital respiratory course than CLD\u2010only, all post\u2010discharge respiratory and neurodevelopmental outcomes were similar. cPH was not associated with death or disability (adjusted odds ratio, 1.02; 95% confidence interval, 0.32\u20133.27). Disease progression treated with sildenafil occurred in 2 (4%) cases. There was no death from respiratory or RV failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Primary treatment of CLD\u2013cPH with diuretics using RV\u2010dilatation as therapeutic threshold, may result in symptomatic improvement, disease stabilization and post\u2010discharge outcomes comparable to infants without cPH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25200","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T15:23:32Z","timestamp":1607009012000},"page":"1155-1164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Short and long\u2010term outcomes of chronic pulmonary hypertension in preterm infants managed using a standardized 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