{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:08:50Z","timestamp":1790255330365,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The association between arginase I (\n ARG1<\/jats:italic>\n ) and arginase II (\n ARG2<\/jats:italic>\n ) genes and asthma has been reported in previous studies, but associations between polymorphisms in\n ARG<\/jats:italic>\n genes and preschool wheezing (PSW) phenotypes are still unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To examine the association between genetic variation in\n ARG1<\/jats:italic>\n and\n ARG2<\/jats:italic>\n genes and PSW phenotypes.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We enrolled 83 patients and 86 healthy controls. The patient group included two subgroups: episodic wheezing (EW) (\n n<\/jats:italic>\n \u2009=\u200942, median age 41 months) and multiple\u2010trigger wheezing (MW) (\n n<\/jats:italic>\n \u2009=\u200941, median age 39 months). We genotyped six single nucleotide polymorphisms (SNPs) in\n ARG1<\/jats:italic>\n and six SNPs in\n ARG2<\/jats:italic>\n . Eighteen haplotypes for\n ARG1<\/jats:italic>\n and 31 haplotypes for\n ARG2<\/jats:italic>\n were constituted, and the distributions of SNPs and haplotypes in patients and controls were analyzed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The frequency of the homozygote cytosine\u2010cytosine (CC) genotype of\n ARG1<\/jats:italic>\n rs2781667T>C SNP and the\n ARG1<\/jats:italic>\n haplotype 4 in the MW group was significantly higher than the EW group (\n p<\/jats:italic>\n \u2009=\u2009.002; odd ratios [OR]: 5.25; confidence interval [CI]: 1.9\u201314.51 and\n p<\/jats:italic>\n \u2009<\u2009.001; OR: 7.77; CI: 2.54\u201323.74, respectively). The frequency of the\n ARG1<\/jats:italic>\n haplotype 5 was significantly higher but the frequency of\n ARG1<\/jats:italic>\n haplotype 9 was significantly lower in the all patients than in the healty controls (\n p<\/jats:italic>\n \u2009=\u2009.019; OR: 10.34; CI: 1.28\u201383.53 and\n p<\/jats:italic>\n \u2009=\u2009.015; OR: 0.093; CI:0.01\u20130.74, respectively). The frequency of the\n ARG1<\/jats:italic>\n haplotype 2 was significantly higher in the EW group than in the MW group (\n p<\/jats:italic>\n \u2009=\u2009.014; OR: 5.68; CI: 1.48\u201321.8).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Variations in\n ARG1<\/jats:italic>\n may potentially be related to phenotypes and risk of PSW.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ppul.25202","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T13:54:04Z","timestamp":1608818044000},"page":"561-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between arginase genes polymorphisms and preschool wheezing phenotypes"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-4210","authenticated-orcid":false,"given":"Pinar","family":"Gokmirza Ozdemir","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy and Immunology Trakya University School of Medicine Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damla","family":"Eker","sequence":"additional","affiliation":[{"name":"Department of Genetics Trakya University School of Medicine Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velat","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology Trakya University School of Medicine Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcin","family":"Beken","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology Trakya University School of Medicine Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Gurkan","sequence":"additional","affiliation":[{"name":"Department of Genetics Trakya University School of Medicine Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehtap","family":"Yazicioglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology Trakya University School of Medicine Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necdet","family":"Sut","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Trakya University School of Medicine Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00057002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00002108"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00199913"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-162"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03364.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.12.020"},{"key":"e_1_2_7_10_1","first-page":"L96","article-title":"Induction of arginase isoforms in the lung during hyperoxia","volume":"275","author":"Que LG","year":"1998","journal-title":"Am J Physiol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.10.030"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2521"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-032599"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.04.010"},{"key":"e_1_2_7_15_1","unstructured":"MedlinePlus. 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