{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:08:53Z","timestamp":1790255333420,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Care variability for children with severe acute asthma has been well documented in high\u2010income countries, yet data from low\u2010 and middle\u2010income regions are lacking. We sought to characterize the magnitude of practice variability in the care of Latin American children to identify opportunities for standardization of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study performed through a retrospective analysis of contemporaneously collected data of children with severe acute asthma admitted to a center contributing to the LARed Network registry between May 2017 and May 2019. Centers were grouped by geographic location: Atlantic (AT), South Pacific (SP), and North Central (NC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 434 children, most received care in hospitals in the AT group (54% [235\/434]), followed by the NC (23% [101\/434]) and SP (23% [98\/434]) groups. The majority of children in the AT (92% [215\/235]) and SP (91% [89\/98]) groups received nebulized salbutamol\/albuterol, while metered\u2010dose inhalers were preferred in the NC group (72% [73\/101]). There was a wide variation in the use of antibiotics: AT (57% [135\/235]), SP (48% [47\/98]), and NC (14% [14\/101]). The same was true for ipratropium bromide: AT (67% [157\/235]), SP (90% [88\/98]), and NC (17% [17\/101]), and aminophylline: AT (57% [135\/235]), NC (5% [5\/101]), and SP (0% [0\/98]). High\u2010flow nasal cannula was the preferred respiratory support modality in the AT (60% [141\/235]) and NC (40% [40\/101]) groups, while bilevel positive airway pressure (BiPAP) use was more common in the SP group (80% [78\/98]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We identified significant variability in care for severe acute asthma. Our findings will help to inform the design of future studies, quality improvement initiatives, and development of practice guidelines within Latin America.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.25212","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T09:07:30Z","timestamp":1608282450000},"page":"384-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Variability in care for children with severe acute asthma in Latin America"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4734-1633","authenticated-orcid":false,"given":"Nicolas","family":"Monteverde\u2010Fernandez","sequence":"first","affiliation":[{"name":"Departamento de Cuidado Critico Pediatrico Red Colaborativa Pedi\u00e1trica de Latinoam\u00e9rica (LARed Network) Montevideo Uruguay"},{"name":"Departamento de Pediatria, Cuidados Intensivos Pedi\u00e1tricos y Neonatales (CINP) Medica Uruguaya Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4763-074X","authenticated-orcid":false,"given":"Franco","family":"Diaz\u2010Rubio","sequence":"additional","affiliation":[{"name":"Departamento de Cuidado Critico Pediatrico Red Colaborativa Pedi\u00e1trica de Latinoam\u00e9rica (LARed Network) Montevideo Uruguay"},{"name":"Departamento de Pediatria Hospital El Carmen de Maip\u00fa Santiago Chile"},{"name":"Departamento de Pediatria, Instituto de Ciencias Biom\u00e9dicas Universidad del Desarrollo Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-5032","authenticated-orcid":false,"given":"Pablo","family":"V\u00e1squez\u2010Hoyos","sequence":"additional","affiliation":[{"name":"Departamento de Cuidado Critico Pediatrico Red Colaborativa Pedi\u00e1trica de Latinoam\u00e9rica (LARed Network) Montevideo Uruguay"},{"name":"Departamento de Pediatr\u00eda Fundaci\u00f3n Universitaria de Ciencias de la Salud Bogot\u00e1 Colombia"},{"name":"Departamento de Pediatr\u00eda Universidad Nacional de Colombia Bogot\u00e1 Colombia"},{"name":"Departamento de Pediatria Unidad de Cuidado intensivo Pedi\u00e1trico, Hospital de San Jos\u00e9 Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-2276","authenticated-orcid":false,"given":"Alexandre T.","family":"Rotta","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria Duke University Medical Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-227X","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Gonz\u00e1lez\u2010Dambrauskas","sequence":"additional","affiliation":[{"name":"Departamento de Cuidado Critico Pediatrico Red Colaborativa Pedi\u00e1trica de Latinoam\u00e9rica (LARed Network) Montevideo Uruguay"},{"name":"Departamento de Pediatria Unidad de Cuidados Intensivos Pedi\u00e1tricos Especializados (CIPe), Casa de Galicia Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the LARed Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"issue":"94","key":"e_1_2_8_2_1","first-page":"1","article-title":"Trends in asthma prevalence, health care use, and mortality in the United States, 2001\u20102010","author":"Akinbami LJ","year":"2012","journal-title":"NCHS Data Brief"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"issue":"2","key":"e_1_2_8_4_1","first-page":"188","article-title":"Prevalence of asthma in Latin America. 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