{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:25:51Z","timestamp":1780730751139,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Interpregnancy interval (IPI) is defined as the period between a live birth and the conception of a subsequent fetus. Both short (IPI\u2009&lt;\u20096 months) and long IPI (IPI\u2009&gt;\u200960 months) have\u00a0been shown to increase the risk for adverse perinatal outcomes, some of which, are known risk factors for obstructive sleep apnea syndrome (OSAS) in the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To study the association between IPI and risk for offspring OSAS, during a follow\u2010up period of up to 18 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Population\u2010based cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>In this population\u2010based cohort analysis, all singleton live births, born to a mother with at least one previous birth occurring between 1991 and 2014, were included. Congenital malformations were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Hospitalizations of the offspring due to OSAS diagnosis up to 18 years of age, were evaluated according to IPI length. Intermediate IPI (6\u201360 months) was considered as the reference. A Kaplan\u2010Meier survival curve and a Cox hazards regression model were used to compare the incidence of OSAS between the groups, and to adjust for confounding variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 144,397 deliveries, of which 13.1% (<jats:italic>n<\/jats:italic>\u2009=\u200918,947) were followed by short IPI, 7.9% (<jats:italic>n<\/jats:italic>\u2009=\u200911,438) and 79.0% (<jats:italic>n<\/jats:italic>\u2009=\u2009114,012) were followed by long and intermediate IPI, respectively. OSAS hospitalization rates were significantly higher among the long IPI group compared to intermediate and short IPIs (0.9%; 0.7% and 0.6%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u2009.001). The association between long IPI and offspring pediatric OSAS remained significant after controlling for preterm delivery, maternal diabetes, and smoking, and mode of delivery, (adjusted HR\u2009=\u20091.45; 95% CI, 1.17\u20131.80).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children born following long IPI are at increased risk for pediatric OSAS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25240","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T18:26:19Z","timestamp":1609439179000},"page":"1085-1091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Short and long interpregnancy interval and the risk for pediatric obstructive sleep apnea in the offspring"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-6652","authenticated-orcid":false,"given":"Hila","family":"Rapaport 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