{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:27:08Z","timestamp":1778603228822,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>Maternal psychosocial stress might be associated with development of allergic diseases in the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the association of maternal depression and anxiety with ever wheezing and recurrent wheezing among infants and to assess the role of maternal hypothalamo\u2010pituatary\u2010adrenal axis changes and fetal immune response in this association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study encompasses two designs; cohort design was developed to evaluate the association of prenatal depression with development of wheezing in infants while nested case\u2013control design was used to assess the role of maternal cortisol and tetranectin and cord blood interleukin 13\u00a0and interferon \u03b3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 697 pregnant women. Elementary school graduate mother (odds ratio [OR]\u2009=\u20091.5, <jats:italic>p<\/jats:italic>\u2009=\u2009.06), maternal smoking during pregnancy (OR\u2009=\u20093.4, <jats:italic>p<\/jats:italic>\u2009=\u2009.001), familial history of asthma (OR\u2009=\u20092.7, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) increased the risk of ever wheezing. Elementary school graduate mother (OR\u2009=\u20092.6, <jats:italic>p<\/jats:italic>\u2009=\u2009.002), maternal smoking during pregnancy (OR\u2009=\u20094.8, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and familial history of asthma (OR\u2009=\u20091.7, <jats:italic>p<\/jats:italic>\u2009=\u2009.01) increased the risk of recurrent wheezing. Maternal previous psychiatric disease, or Edinburgh Postnatal Depression Scale or Spielberger State\u2010Trait Anxiety Inventory scores were not associated with wheezing. Maternal tetranectin levels were significantly higher among never wheezers compared to the ever wheezers (264.3\u2009\u00b1\u2009274.8 vs. 201.6\u2009\u00b1\u2009299.7, <jats:italic>p<\/jats:italic>\u2009=\u2009.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, the major risk factors for ever wheezing and recurrent wheezing were maternal smoking, level of education and family history of asthma. However, maternal depression and anxiety were not determined as risk factors for wheezing. Maternal tetranectin carries potential as a biomarker for wheezing in the infant.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25302","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T13:09:47Z","timestamp":1613653787000},"page":"1573-1582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maternal psychiatric status and infant wheezing: The role of maternal hormones and cord blood cytokines"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-5020","authenticated-orcid":false,"given":"Ozge","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy and Pulmonology Celal Bayar University Medical Faculty Manisa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adem","family":"Yasar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Pulmonology Celal Bayar 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