{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T21:53:17Z","timestamp":1788126797560,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U10 HL109250"],"award-info":[{"award-number":["U10 HL109250"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperpolarized gas with helium (HHe\u20103) MR (magnetic resonance) is a noninvasive imaging method which maps and quantifies regions of ventilation heterogeneity (VH) in the lung. VH is an important feature of asthma, but little is known as to how VH informs patient phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine if VH indicators quantified by HHe\u20103 MR imaging (MRI) predict phenotypic characteristics and map to regions of inflammation in children with problematic wheeze or asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty children with poorly\u2010controlled wheeze or asthma underwent HHe\u20103 MRI, including 22 with bronchoalveolar lavage (BAL). The HHe\u20103 signal intensity defined four ventilation compartments. The non\u2010ventilated and hypoventilated compartments divided by the total lung volume defined a VH index (VHI %).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with VHI % in the upper quartile had significantly greater airflow limitation, bronchodilator responsiveness, blood eosinophils, expired nitric oxide (FeNO), and BAL eosinophilic or neutrophilic granulocyte patterns compared to children with VHI % in the lower quartile. Lavage return from hypoventilated bronchial segments had greater eosinophil % than from ventilated segments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In children with asthma, greater VHI % as measured by HHe\u20103 MRI identifies a severe phenotype with higher type 2 inflammatory markers, and maps to regions of lung eosinophilia. Listed on ClinicalTrials. gov (NCT02577497).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25303","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T23:08:18Z","timestamp":1614121698000},"page":"1440-1448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Measures of ventilation heterogeneity mapped with hyperpolarized helium\u20103 MRI demonstrate a T2\u2010high phenotype in asthma"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-606X","authenticated-orcid":false,"given":"W.","family":"Gerald Teague","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Child Health Research Center University of Virginia School of Medicine Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Mata","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging University of Virginia School of Medicine Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Qing","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging University of Virginia School of Medicine Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Tustison","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging University of Virginia School of Medicine Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Mugler","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging University of Virginia School of Medicine Charlottesville Virginia USA"},{"name":"Department of Biomedical Engineering University of Virginia Charlottesville Virginia 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