{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:19:54Z","timestamp":1758809994943,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:00:00Z","timestamp":1615593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lung ultrasound (LUS) and lung ultrasound score (LUSS) have been successfully used to diagnose neonatal pneumonia, assess the lesion distribution, and quantify the aeration loss. The present study design determines the diagnostic value of LUSS in the semi\u2010quantitative assessment of pneumonia in coronavirus disease 2019 (COVID\u201019) neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven COVID\u201019 neonates born to mothers with COVID\u201019 infection and 11 age\u2010 and gender\u2010matched controls were retrospectively studied. LUSS was acquired by assessing the lesions and aeration loss in 12 lung regions per subject.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most of the COVID\u201019 newborns presented with mild and atypical symptoms, mainly involving respiratory and digestive systems. In the COVID\u201019 group, a total of 132 regions of the lung were examined, 83 regions (62.8%) of which were detected abnormalities by LUS. Compared with controls, COVID\u201019 neonates showed sparse or confluent B\u2010lines (83 regions), disappearing A\u2010lines (83 regions), abnormal pleural lines (29 regions), and subpleural consolidations (2 regions). The LUSS was significantly higher in the COVID\u201019 group. In total, 49 regions (37%) were normal, 73 regions (55%) scored 1, and 10 regions (8%) scored 2 by LUSS. All the lesions were bilateral, with multiple regions involved. The majority of the lesions were located in the bilateral inferior and posterior regions. LUS detected abnormalities in three COVID\u201019 neonates with normal radiological performance. The intra\u2010observer and inter\u2010observer reproducibility of LUSS was excellent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LUS is a noninvasive, convenient, and sensitive method to assess neonatal COVID\u201019 pneumonia, and can be used as an alternative to the use of diagnostic radiography. LUSS provides valuable semi\u2010quantitative information on the lesion distribution and severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25325","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T19:16:01Z","timestamp":1615662961000},"page":"1419-1426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Quantitative assessment of COVID\u201019 pneumonia in neonates using lung ultrasound score"],"prefix":"10.1002","volume":"56","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasonics, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manli","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingkong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Wuhan Children's Hospital (Wuhan Maternal and Child 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