{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:37:53Z","timestamp":1770741473781,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our aim in this study was to assess the effect of the Predictive Intelligent Control of Oxygenation (PRICO<jats:sup>\u00ae<\/jats:sup>) system on cerebral (rSO<jats:sub>2<\/jats:sub>C) and splanchnic (rSO<jats:sub>2<\/jats:sub>S) oxygenation in a cohort of preterm infants with frequent desaturations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty infants with gestational age &lt;32 weeks (<jats:italic>n<\/jats:italic>\u2009=\u200920) were assigned in random sequence to 12\u2009h of automated or manual adjustment of FiO<jats:sub>2<\/jats:sub>. Over\u00a0this period, they were studied continuously by near\u2010infrared spectroscopy (NIRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that rSO<jats:sub>2<\/jats:sub>C [68.0% (60.5%\u201374.7%) vs.\u00a068.5% (62%\u201372%); <jats:italic>p<\/jats:italic>\u2009=\u2009.824] and rSO<jats:sub>2<\/jats:sub>S [27.0% (17.3%\u201345.7%) vs.\u00a027.0% (15%\u201353%); <jats:italic>p<\/jats:italic>\u2009=\u2009.878] were similar during automatic and manual control of FiO<jats:sub>2<\/jats:sub>. Time spent with SpO<jats:sub>2<\/jats:sub> 90%\u201395% was higher during the automatic than manual control of FiO<jats:sub>2<\/jats:sub>, while time spent with SpO<jats:sub>2<\/jats:sub> &lt;80% or &gt;95% was lower.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Automated control of FiO<jats:sub>2<\/jats:sub> with PRICO<jats:sup>\u00ae<\/jats:sup> system did not improve brain and splanchnic oxygenation in comparison with manual control in a cohort of preterm infants, but it significantly decreased SpO<jats:sub>2<\/jats:sub> fluctuations and limited the duration of both hypoxemia and hyperoxemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25379","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T20:21:11Z","timestamp":1616790071000},"page":"2067-2072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cerebral and splanchnic oxygenation during automated control of inspired oxygen (FiO<sub>2<\/sub>) in preterm infants"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-621X","authenticated-orcid":false,"given":"Carlo","family":"Dani","sequence":"first","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence  Florence Italy"},{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health Careggi University Hospital of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Pratesi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Luzzati","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Petrolini","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Montano","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Remaschi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Coviello","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1609"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-018-0084-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-017-2404-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1576"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499361"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.08.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514212"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302298"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911781"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.8841"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24238"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.10.007"},{"key":"e_1_2_9_14_1","first-page":"F360","article-title":"Effects of a new device for automated closed loop control of inspired oxygen concentration on fluctuations of arterial and different regional organ tissue oxygen saturations in preterm infants","volume":"104","author":"Gajdos M","year":"2019","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2016.03.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.158"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200002000-00008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340100994"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0249"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01955"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318287e9d7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311647"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.8841"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25379","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T13:18:18Z","timestamp":1693401498000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/ppul.25379"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25379","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,26]]},"assertion":[{"value":"2020-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}