{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:38:17Z","timestamp":1788241097339,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Multidose dexamethasone pretreatment reduces risk of postextubation airway obstruction (PEAO). However, its optimal dose is not known. We planned to compare 24\u2009h pretreatment with low\u2010dose dexamethasone (LDD) (0.25 mg\/kg\/dose) versus high\u2010dose dexamethasone (HDD) (0.5 mg\/kg\/dose) in reducing risk of PEAO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Stratified (for age and intubation duration) randomized open\u2010label noninferiority trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Fifteen\u2010bed pediatric intensive care unit in a lower\u2010middle\u2010income country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Children (3 months\u201312 years) intubated for more than or equal to 48\u2009h and planned for first extubation (February 17\u2013March 19). Upper airway conditions, chronic respiratory diseases, chronic NSAID therapy, steroid, or intravenous immunoglobulin in the last 7 days, presence of gastrointestinal bleeding, hypertension, and hyperglycemia were exclusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>LDD (<jats:italic>n\u2009<\/jats:italic>=\u2009144) or HDD (<jats:italic>n\u2009<\/jats:italic>=\u2009143) (q6h) for a total of six doses. Extubation was planned immediately after fifth dose. Noninferiority margin was kept at 12% from baseline.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25388","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T10:51:38Z","timestamp":1616669498000},"page":"2292-2301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Twenty\u2010four\u2010hour pretreatment with low dose (0.25\u2009mg\/kg\/dose) versus high dose (0.5\u2009mg\/kg\/dose) dexamethasone in reducing the risk of postextubation airway obstruction in children: A randomized open\u2010label noninferiority trial"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2853-4330","authenticated-orcid":false,"given":"Biraj","family":"Parajuli","sequence":"first","affiliation":[{"name":"Department of Pediatrics Chitwan Medical College  Bharatpur 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