{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:18:06Z","timestamp":1767853086996,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the beneficial effects of synchronized intermittent mandatory ventilation (SIMV) with heliox in newborn infants with meconium aspiration syndrome (MAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010one newborn infants with MAS in the neonatal intensive care unit (NICU) of Daping Hospital of Army Medical University were enrolled in the trial. Infants treated with SIMV were randomized and divided into the heliox group (<jats:italic>n<\/jats:italic>\u2009=\u200935) and control group (<jats:italic>n<\/jats:italic>\u2009=\u200936). The heliox group received heliox for 6\u2009h followed by air\u2010oxygen mixed gas, and the control group received air\u2010oxygen mixed gas. The primary outcome measures were PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> (P\/F) and the extubation time. The secondary outcome measures were the incidence of mechanical ventilation complications, hospital length of stay in the NICU, blood gas analysis, and inflammation markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The P\/F in the heliox group was significantly better than that in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The extubation time and hospital length of stay in the NICU in the heliox group were shorter than those in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The inflammation markers at 6\u2009h and myocardial injury markers at 24\u2009h were decreased compared with those at 0\u2009h, and those in the heliox group were more significantly decreased than those in the control group ([interleukin {IL}\u20106\/IL\u20108\/tumor necrosis factor \u03b1] <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, [C\u2010reaction protein] <jats:italic>p<\/jats:italic>\u2009=\u2009.012; [creatine kinase] <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, [CK\u2010MB] <jats:italic>p<\/jats:italic>\u2009=\u2009.041).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Heliox appears to be more effective in reducing the length of ventilation and increasing carbon dioxide eliminations than an air\u2010oxygen mixture in infants with MAS under the support of SIMV.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25390","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T22:05:36Z","timestamp":1617919536000},"page":"2087-2093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A randomized single\u2010center controlled trial of synchronized intermittent mandatory ventilation with heliox in newborn infants with meconium aspiration syndrome"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2530-2043","authenticated-orcid":false,"given":"Juan","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pediatrics North\u2010Kuanren General Hospital  Chongqing China"},{"name":"Department of Pediatrics, Daping Hospital Army Medical University  Chongqing 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