{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:44:16Z","timestamp":1790876656153,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In chronic asthma treatment, leukotriene receptor antagonists have been recommended, but it is not clear whether montelukast can be used in acute recurrent wheezing attacks in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the safety and effectiveness of oral montelukast in addition to standard treatment in hospitalized children aged between 6 and 72 months with acute recurrent wheezing attacks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>One hundred patients aged between 6 and 72 months who had wheezing attacks with clinical asthma scores (CAS) \u22653 and were hospitalized were included in this randomized, double\u2010blind, placebo\u2010controlled, parallel\u2010group clinical trial. All the patients included in the study were given 0.15\u2009mg\/kg (maximum 5\u2009mg) nebulized salbutamol (8\u2009L\/min and with 100% O<jats:sub>2<\/jats:sub>) with 4\u2009h\u00a0of intervals, 1\u2009mg\/kg prednisolone (maximum 5 days), nebulized ipratropium bromide (total eight doses) with 6\u2009h\u00a0of intervals. In addition to this treatment, one group received 4\u2009mg montelukast, and the other group received a placebo. The CAS\u00a0of the patients were evaluated with 4\u2010h\u00a0intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total hospital length of stay (LOS) was not different between the montelukast and placebo groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.981). There was no statistically significant difference between the two treatment groups in terms of discharge time, CAS, and oxygen saturation (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adding montelukast to standard treatment in patients hospitalized for moderate\u2010to\u2010severe wheezing attacks did not affect hospital LOS and CAS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25394","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T21:16:29Z","timestamp":1618262189000},"page":"1931-1937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of using montelukast during acute wheezing attack in hospitalized preschool children on the discharge rate and the clinical asthma score"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5746-6835","authenticated-orcid":false,"given":"Emine","family":"Demet Akba\u015f","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology D\u00f6rt\u00e7elik Children's Hospital  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0005-1409","authenticated-orcid":false,"given":"Cem H.","family":"Razi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Atilim University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesibe","family":"And\u0131ran","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology G\u00fcven Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138707"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.017244"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2016.11.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311368"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-8603-9_6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.supplement_1.ltta-15"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.15.1181"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.11.1213"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91709-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.6_Pt_1.1442"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.121456"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200301000-00009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.4.255"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.3.221"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.6.505"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01615.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00500.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250443"},{"key":"e_1_2_7_20_1","unstructured":"T\u00fcrk ToraksD Ast\u0131mT TedaviR.G\u00fcncellemesi.\u00a02016.http:\/\/www.toraks.org.tr\/book.aspx?list=2212%26menu=288"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(94)70347-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(96)00027-3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9912111"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.e48"},{"key":"e_1_2_7_25_1","first-page":"290S","article-title":"Evaluation of the long\u2010term effect of montelukast in adult (\u2009\u2265\u200915\u2009years) and pediatric (6\u2010 to 14\u2010years) patients","volume":"14","author":"Knorr B","year":"1999","journal-title":"Eur Respir J"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.11.015"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.135038"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-13-20"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2003.1479"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-38-29"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/pec.0b013e31815f3968"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.168567"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2009.11.065"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000001184"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61073-3"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70186-9"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200406000-00004"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25394","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T13:17:24Z","timestamp":1693401444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,12]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/ppul.25394"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25394","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,12]]},"assertion":[{"value":"2020-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}