{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:04:25Z","timestamp":1782882265981,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ventilated neonates with hypoxemic respiratory failure (HRF) may show a ventilation\u2010perfusion (V\/Q) mismatch.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the difference between the Bohr (V<jats:sub>d, Bohr<\/jats:sub>) and Enghoff (V<jats:sub>d, Enghoff<\/jats:sub>) dead spaces in infants by using volumetric capnography based on ventilator graphics and capnograms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study enrolled 46 ventilated infants (mean birth weight, 2239\u2009\u00b1\u2009640\u2009g; mean gestational age, 35.5\u2009\u00b1\u20093.3 weeks). We performed volumetric capnography and calculated V<jats:sub>d, Bohr<\/jats:sub> and V<jats:sub>d, Enghoff<\/jats:sub> when arterial blood sampling was necessary for treatment. According to the oxygenation index (OI) based on the Montreux definition of neonatal acute respiratory distress syndrome, each measurement was classified into the HRF (OI\u2009\u2265\u20094) or control (OI\u2009&lt;\u20094) group. Then, a regression analysis was performed to evaluate the correlation between the OI and the difference between V<jats:sub>d, Enghoff<\/jats:sub> and V<jats:sub>d, Bohr<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median V<jats:sub>d, Enghoff<\/jats:sub>\/tidal volume (V<jats:sub>T<\/jats:sub>) was significantly higher in the HRF group (0.55 [interquartile range, 0.47\u20130.68]) than in the control group (0.46 [0.37\u20130.57]). The HRF group showed a larger difference between V<jats:sub>d, Enghoff<\/jats:sub>\/V<jats:sub>T<\/jats:sub> and V<jats:sub>d, Bohr<\/jats:sub>\/V<jats:sub>T<\/jats:sub> than the control group (median, 0.22 [0.15\u20130.29] vs. 0.10 [0.06\u20130.14], respectively). Moreover, the regression analysis of the relationship between OI and V<jats:sub>d, Enghoff<\/jats:sub>\/V<jats:sub>T<\/jats:sub>\u2009\u2212\u2009V<jats:sub>d, Bohr<\/jats:sub>\/V<jats:sub>T<\/jats:sub> showed a positive correlation (<jats:italic>r<\/jats:italic>\u2009=\u2009.60, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ventilated neonates with hypoxemic respiratory failure showed a large difference between V<jats:sub>d, Enghoff<\/jats:sub> and V<jats:sub>d, Bohr<\/jats:sub>, possibly reflecting a low V\/Q mismatch and right\u2010to\u2010left shunting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25403","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T20:10:08Z","timestamp":1618776608000},"page":"2102-2107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Large difference between Enghoff and Bohr dead space in ventilated infants with hypoxemic respiratory failure"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7055-3554","authenticated-orcid":false,"given":"Masashi","family":"Zuiki","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Kyoto Japan"},{"name":"Department of Pediatrics, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kamigyo\u2010ku Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Kume","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amane","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Mitsuno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuyo","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11146"},{"key":"e_1_2_10_3_1","first-page":"453","article-title":"Respiratory monitoring in adult intensive care unit. 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