{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:46:48Z","timestamp":1760986008657,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little attention has been given to the long\u2010term respiratory outcomes of children with gastroschisis. The purpose of this study was to determine if gastroschisis survivors have more respiratory illnesses in their first 10 years of life compared with age\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study of all gastroschisis children born in Manitoba between 1991 and 2017. Gastroschisis cases were identified from a clinical database, and a date of birth\u2010matched control cohort was constructed from a population\u2010based data repository. International Classification of Disease codes were used to compare the risk and frequency of respiratory diagnoses for children with gastroschisis to date of birth\u2010matched controls from 0\u20135 years of age and 5\u201310 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 0\u20135 years of age analysis included 117 gastroschisis cases and 1205 date of birth\u2010matched controls; children with gastroschisis had a higher risk of asthma (relative risk [RR]\u2009=\u20091.46; 95% confidence interval [CI]: 1.03, 2.55; <jats:italic>p<\/jats:italic>\u2009=\u2009.029), acute bronchitis\/bronchiolitis (RR\u2009=\u20091.61; 95% CI: 1.27, 2.03; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), pneumonia (RR\u2009=\u20091.99; 95% CI: 1.45, 2.72; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), viral pneumonia (RR\u2009=\u20095.15; 95% CI: 1.79, 14.81; <jats:italic>p<\/jats:italic>\u2009=\u2009.007), and pneumonia due to unspecified organism (RR\u2009=\u20092.06; 95% CI: 1.45, 2.92; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Gastroschisis children 0\u20135 years of age were also diagnosed more frequently with bronchitis\/bronchiolitis (RR\u2009=\u20092.14; 95% CI: 1.79, 2.57; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and viral pneumonia (RR\u2009=\u20098.10; 95% CI: 3.79, 17.31; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The 5\u201310 years of age analysis included 73 cases and 738 controls; no difference in the risk of respiratory illness was found for gastroschisis cases and controls in this age group. However, gastroschisis cases were more frequently diagnosed with bacterial pneumonia (RR\u2009=\u20093.03; 95% CI: 1.67, 5.51; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and influenza (RR\u2009=\u20093.03; 95% CI: 1.67, 5.51; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that children with gastroschisis have an increased risk of asthma and respiratory infections compared with children without gastroschisis, most noticeably in the first 5 years of life.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25404","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T10:54:56Z","timestamp":1617620096000},"page":"2302-2311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Respiratory outcomes in the first 10 years of life in children with gastroschisis: A retrospective cohort study"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9836-7040","authenticated-orcid":false,"given":"Osamuyi","family":"Asemota","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery, Children's Hospital Research Institute of Manitoba University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Derraugh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery, Children's Hospital Research Institute of Manitoba University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Levesque","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery, Children's Hospital Research Institute of Manitoba University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaikh","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Balshaw","sequence":"additional","affiliation":[{"name":"Centre for Healthcare Innovation University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2613-0498","authenticated-orcid":false,"given":"Suyin A.","family":"Lum Min","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery, Children's Hospital Research Institute of Manitoba University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Pediatrics and Child Health University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-3157","authenticated-orcid":false,"given":"Richard","family":"Keijzer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery, Children's Hospital Research Institute of Manitoba University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Pediatrics and Child Health University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30181"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2018.1438890"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14833"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00183736"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30408-X"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.115188"},{"key":"e_1_2_10_8_1","unstructured":"Global Asthma Network. 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