{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:22Z","timestamp":1786978402475,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072351"],"award-info":[{"award-number":["82072351"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This report summarizes the clinical features and 1\u2010month follow\u2010up observations for pediatric patients who were hospitalized with coronavirus disease 2019 (COVID\u201019) in Wuhan Women and Children's Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The 1\u2010month follow\u2010up data included clinical manifestations and results from serum severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) IgG\u00a0and IgM tests, reverse\u2010transcription polymerase chain reaction (RT\u2010PCR) for SARS\u2010CoV\u20102, lung computed tomography (CT) scans, and laboratory tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between January 20 and March 15, 2020, 127 patients aged 0\u201315 years were hospitalized for COVID\u201019 treatment, including 3 severe cases and 124 mild or moderate cases. The main therapies included inhalation of aerosolized interferon\u2010\u03b1 (122\/127) and additional antiviral drugs (28\/127). Among the 81 patients who had pneumonia at admission, 35 with right lobe pneumonia had the longest hospital stay (mean 14.5\u2009\u00b1\u20097 days); 17 with left lobe pneumonia had the highest creatine kinase (154\u2009\u00b1\u2009106\u2009U\/L) and creatine kinase myocardial band \u00a0(CK\u2010MB, 43\u2009\u00b1\u200948\u2009U\/L) levels; and 29 with bilateral pneumonia had the highest white blood cell counts (8.3\u2009\u00b1\u20094\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L). Among the 46 patients who were successfully followed up 1 month after discharge, two notable findings were right lobe pneumonia in 22% (95% confidence interval [CI]: 11%\u201337%) of patients and persistently elevated serum creatine kinase and CK\u2010MB levels. The median duration of elevated CK\u2010MB was 45 days. The mean concentrations of serum SARS\u2010CoV\u20102 IgG and IgM in 41 patients were 8.0\u2009\u00b1\u20097.5 and 98\u2009\u00b1\u200940\u2009ng\/ml, respectively. At follow\u2010up, four patients retested positive for SARS\u2010CoV\u20102.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The involvement of different lung lobes in patients with COVID\u201019 was associated with variations in the persistence of pneumonia and elevation of CK\u2010MB levels and body temperature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.25407","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T01:56:38Z","timestamp":1618451798000},"page":"1967-1975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical features and follow\u2010up of pediatric patients hospitalized for COVID\u201019"],"prefix":"10.1002","volume":"56","author":[{"given":"Feng","family":"Tang","sequence":"first","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Luo","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Mei","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Shao","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9753-2924","authenticated-orcid":false,"given":"Qifa","family":"Song","sequence":"additional","affiliation":[{"name":"Medicine Research Center Ningbo City First Hospital  Ningbo Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000044"},{"key":"e_1_2_9_3_1","unstructured":"WHO. COVID\u201019 weekly epidemiological update.https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20210309_weekly_epi_update_30.pdf. Accessed March 16 2021."},{"issue":"2","key":"e_1_2_9_4_1","first-page":"145","article-title":"The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID\u201019) in China","volume":"41","author":"Novel Coronavirus Pneumonia Emergency Response Epidemiology Team","year":"2020","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020105896"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30198-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa301"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24978"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30701-5"},{"key":"e_1_2_9_10_1","unstructured":"National Health and Health Commission\u00a0of the people's Republic of China.\u00a0Diagnosis and treatment guidelines for 2019 novel coronavirus pneumonia (Draft version 7)[EB\/OL].2020.http:\/\/www.nhc.gov.cn\/yzygj\/s7653p\/202002\/3b09b894ac9b4204a79db5b8912d4440.shtml. (Chinese).\u00a0Accessed March 5 2020."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"issue":"1","key":"e_1_2_9_12_1","first-page":"1","article-title":"Diagnosis and treatment recommendation for pediatric coronavirus disease\u201019","volume":"49","author":"Chen Z","year":"2020","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_9_13_1","unstructured":"National Health and Health Commission of the people's Republic of China.Guidelines on diagnosis and treatment of novel coronavirus pneumonia (interim 8th edition).http:\/\/www.nhc.gov.cn\/yzygj\/s7652m\/202008\/475d0199d34c4cac840eb7998fad444f.shtml(Chinese)."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200432"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00375"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30397-2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25070"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15528"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/38.12.2396"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.0950"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa190"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd6165"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30651-4"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25245"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12386"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07636-4"},{"issue":"4","key":"e_1_2_9_27_1","first-page":"209","article-title":"Influenza\u2010related viral myocarditis","volume":"109","author":"Rezkalla SH","year":"2010","journal-title":"WMJ"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T09:15:55Z","timestamp":1693386955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/ppul.25407"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25407","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,14]]},"assertion":[{"value":"2020-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}