{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:32:36Z","timestamp":1774438356984,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary arterial hypertension (PAH) is a rare disease in children, with significant mortality. Because of the limited research on pediatric PAH, first, systematic review of related drugs is conducted, and then economic evaluation of PAH drug treatment programs is conducted, which to provide a reference for the choice of more cost\u2010effective treatment options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The search includes electronic databases such as Pubmed, ScienceDirect, and Embase. Through inclusion and exclusion criteria, screen high\u2010quality randomized controlled trials. We used TreeAge Pro 2011 software to construct the markov model, that to simulate the total medical cost and quality\u2010adjusted life years (QALYs), and to calculate the incremental cost\u2010effectiveness ratio. Sensitivity analysis of transfer probability, utility, and cost was carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incorporate two studies that meet the criteria, one compared the therapeutic effects of bosentan and placebo on pediatric PAH, the other compared therapeutic effects of sildenafil and placebo on pediatric PAH, both articles were of good quality. Compared with the sildenafil group (3.38QALYs and $161,120.14), the QALY of the bosentan treatment group (3.33QALYs and $257,411.29) was reduced by 0.05, and the cost increased by $96,291.15. The estimated improvement to quality of life and reduced costs result in an estimate of economic dominance for sildenafil over bosentan. This dominant result persisted probabilistic analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on this model, a more cost\u2010effective treatment drug for PAH in children is sildenafil.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25427","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T02:05:22Z","timestamp":1618538722000},"page":"2250-2258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Systematic review and cost\u2010effectiveness of bosentan and sildenafil as therapeutic drugs for pediatric pulmonary arterial hypertension"],"prefix":"10.1002","volume":"56","author":[{"given":"Tingting","family":"Chen","sequence":"first","affiliation":[{"name":"School of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahe","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Health Economics, School of Pharmacy University of Southern California  Los Angeles California USA"},{"name":"Leonard D. Schaeffer Center for Health Policy and Economics University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoxin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanrui","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8382-7868","authenticated-orcid":false,"given":"Maobai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-013-0052-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.969584"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00056110"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4065\/83.8.923"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00005713"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711580408"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.029"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2004.06.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000329"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.06.064"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0969"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005698"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.08.080"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.11.009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/11317820-000000000-00000"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-015-0366-8"},{"issue":"4","key":"e_1_2_8_20_1","first-page":"115","article-title":"Nursing matters: the nursing and health outcomes project of the ontario ministry of health and long\u2010term care","volume":"33","author":"Pringle DM","year":"2002","journal-title":"Can J Nurs Res"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/11630780-000000000-00000"},{"issue":"2","key":"e_1_2_8_22_1","first-page":"170","article-title":"Standards of care in pulmonary hypertension","volume":"61","author":"Barber\u00e0 JA","year":"2008","journal-title":"Rev Esp Cardiol"},{"key":"e_1_2_8_23_1","unstructured":"U.S. Food and Drug Administration. 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