{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:33:17Z","timestamp":1773282797092,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the efficacy and safety of high\u2010frequency oscillation ventilation combined with volume guarantee (HFOV\u2010VG) compared with the safety and efficacy of HFOV alone in infants with acute hypoxemic respiratory failure (AHRF) after congenital heart surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the clinical data of 44 infants who were ventilated for AHRF after congenital heart surgery between January 2020 and January 2021. HFOV alone was used in 23 of the 44 infants, whereas HFOV\u2010VG was used in the other 21 infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average frequency tidal volume (VThf) of the HFOV\u2010VG group was lower than that of the HFOV group, and the proportion of VThf exceeding the target range of infants in the HFOV\u2010VG group was also lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). In addition, the incidence of hypocapnia and hypercapnia in infants supported with HFOV\u2010VG was significantly lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Furthermore, the duration of invasive ventilation and the median ventilator adjustment per hour in the HFOV\u2010VG group was also lower than that in the HFOV group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with HFOV alone, HFOV\u2010VG decreases the fluctuation of VThf and the incidence of hypercapnia and hypocapnia. Moreover, it reduces the workload of bedside medical staff. Further studies are needed to confirm the efficacy and safety of HFOV\u2010VG as a routine respiratory support strategy for congenital heart disease during the perioperative period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25447","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T08:24:30Z","timestamp":1620548670000},"page":"2621-2626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Application of high\u2010frequency oscillation ventilation combined with volume guarantee in infants with acute hypoxic respiratory failure after congenital heart surgery"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9468-3647","authenticated-orcid":false,"given":"Yi\u2010Rong","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Fujian Maternity and Child Health Hospital Affiliated Hospital of Fujian Medical University  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