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Animal model of pulmonary hypoplasia induced by amniotic fluid drainage is partly attributed to changes in mechanical compression of the lung. Although numerous studies on OH\u2010model have demonstrated changes in several individual proteins, however, the underlying mechanisms for interrupting normal lung development in response to a decrease of amniotic fluid volume are not fully understood. In this study, we used a proteomic approach to explore differences in the expression of a wide range of proteins after induction of OH in a mouse model of pulmonary hypoplasia to find out the signaling\/molecular pathways involved in fetal lung development. Liquid chromatography\u2010massspectromery\/mass spectrometry analysis found 474 proteins that were differentially expressed in OH\u2010induced hypoplastic lungs in comparison to untouched (UnT) control. Among these proteins, we confirmed the downregulation of AKT1, SP\u2010D, and CD200, and provided proof\u2010of\u2010concept for the first time about the potential role that these proteins could play in fetal lung development.<\/jats:p>","DOI":"10.1002\/ppul.25525","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T11:57:34Z","timestamp":1623239854000},"page":"2740-2750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Proteomic analysis of a murine model of lung hypoplasia induced by oligohydramnios"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1453-9803","authenticated-orcid":false,"given":"Tanbir","family":"Najrana","sequence":"first","affiliation":[{"name":"Department of Pediatrics Women and Infants Hospital\/Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Department of Pathology and Laboratory 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