{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:07:51Z","timestamp":1790874471113,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Respiratory distress syndrome (RDS) and ventilation\u2010induced lung injury lead to significant morbidity in preterm infants. High\u2010frequency oscillatory ventilation with volume\u2010guarantee (HFOV\u2010VG) has been used as a rescue therapy and might lead to lower rates of death and bronchopulmonary dysplasia, especially when using low tidal volumes and high frequencies. The aim of the study was to define HFOV\u2010VG parameters leading to adequate ventilation in the first 72\u2009h of preterm RDS using a low volume and high\u2010frequency strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>Retrospective cohort study in a tertiary\u2010level neonatology unit. Infants &lt;32 weeks with severe respiratory insufficiency needing HFOV\u2010VG were included. Patients were ventilated following a standard mechanical ventilation aiming for low tidal volumes and high frequencies. Clinical data, perinatal characteristics and high\u2010frequency parameters corresponding with adequate ventilation were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>116 patients were included. Median gestational age was 25 weeks (interquartile range [IQR]\u2009=\u200924\u201327), median birth weight 724\u2009g\u00a0(IQR\u2009=\u2009600\u2013900\u2009g). HFOV\u2010VG was started at 2\u2009h, median high\u2010frequency tidal volume was 1.63\u2009ml\/kg (IQR\u2009=\u20091.44\u20131.84) and median frequency was 16\u2009Hz (IQR\u2009=\u200915\u201318). Weight\u2010adjusted tidal volumes did not depend on gestational age, antenatal corticosteroids nor chorioamnionitis, and were inversely correlated with frequencies (<jats:italic>R<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u2009\u22120.10, <jats:italic>p<\/jats:italic>\u2009=\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HFOV\u2010VG can reach adequate ventilation at high frequencies when using adequate volumes, providing a feasible ventilation strategy that might be of help in preterm infants with RDS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25529","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T20:05:06Z","timestamp":1623269106000},"page":"2597-2603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Target volume\u2010guarantee in high\u2010frequency oscillatory ventilation for preterm respiratory distress syndrome: Low volumes and high frequencies lead to adequate ventilation"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2256-8572","authenticated-orcid":false,"given":"Gonzalo","family":"Sol\u00eds\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Division of Neonatology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Gonz\u00e1lez\u2010Pacheco","sequence":"additional","affiliation":[{"name":"Division of Neonatology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ramos\u2010Navarro","sequence":"additional","affiliation":[{"name":"Division of Neonatology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-6979","authenticated-orcid":false,"given":"Ana","family":"Rodr\u00edguez S\u00e1nchez de la Blanca","sequence":"additional","affiliation":[{"name":"Division of Neonatology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"S\u00e1nchez\u2010Luna","sequence":"additional","affiliation":[{"name":"Division of Neonatology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000104.pub4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003666.pub4"},{"key":"e_1_2_6_4_1","article-title":"High\u2010frequency oscillatory ventilation combined with volume guarantee in a neonatal animal model of respiratory distress syndrome","volume":"2013","author":"S\u00e1nchez Luna M","year":"2013","journal-title":"Crit Care Res Pract"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.39"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000437204"},{"key":"e_1_2_6_7_1","first-page":"26","article-title":"Effect of volume guarantee in preterm infants on high\u2010frequency oscillatory ventilation: a pilot study","volume":"34","author":"Enomoto M","year":"2017","journal-title":"Am J 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