{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:52:13Z","timestamp":1787021533240,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The efficacy and safety of surfactant administration via thin catheter in preterm infants with neonatal respiratory distress syndrome (NRDS) was investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, Cochrane Library, and Web of Science databases were searched to identify randomized controlled trials (RCTs) that comparing thin catheter technique with intubation for surfactant delivery in preterm infants with NRDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirteen RCTs (1931 infants) were included in the meta\u2010analysis. The use of thin catheter technique decreased the incidences of bronchopulmonary dysplasia (BPD), pneumothorax, and hemodynamically significant patent ductus arteriosus (hsPDA) (risk ratio [RR]: 0.59, 95% confidence interval [CI]: 0.46\u20130.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001; RR: 0.60, 95% CI: 0.39\u20130.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.02 and RR: 0.88, 95% CI: 0.78\u20131.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.04, respectively). In addition, infants in the intervention group required less mechanical ventilation within 72\u2009h of life or during hospitalization (RR: 0.60, 95% CI: 0.48\u20130.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00001 and RR: 0.64, 95% CI: 0.49\u20130.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0005, respectively) compared with infants in the control group. However, the rate of surfactant reflux was higher in the intervention group than that in the control group (RR: 2.12, 95% CI: 1.37\u20133.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0008). There were no significant differences in mortality and other outcomes between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The administration of surfactant via thin catheter could lower the requirement for mechanical ventilation, and decrease the incidence of BPD, pneumothorax, and hsPDA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.25545","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T17:06:49Z","timestamp":1625245609000},"page":"3013-3025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy and safety of surfactant administration via thin catheter in preterm infants with neonatal respiratory distress syndrome: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"56","author":[{"given":"Xiaohong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Third Affifiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhoushan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Sixth Affifiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Third Affifiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyu","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Third Affifiliated Hospital of Guangzhou Medical University  Guangzhou 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