{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:51:29Z","timestamp":1773424289165,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe six teenagers presenting with fever and severe abdominal symptoms admitted with concerns for multisystem inflammatory syndrome in children (MIS\u2010C). Laboratory evaluation revealed elevated markers of inflammation, lymphopenia, and increased D\u2010dimers. Imaging studies revealed multifocal airspace disease and ground\u2010glass opacities. SARS\u2010CoV\u20102 polymerase chain reaction and serologies were negative. All patients reported a history of vaping, prompting E\u2010cigarette, or vaping, product use\u2010associated lung injury (EVALI) diagnosis. MIS\u2010C has overlapping clinical and laboratory features highlighting the added challenge of diagnosing EVALI during the COVID\u201019 pandemic.<\/jats:p><jats:p><jats:bold>Keywords<\/jats:bold> COVID\u201019 pandemic, EVALI, MIS\u2010C<\/jats:p>","DOI":"10.1002\/ppul.25558","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T08:14:31Z","timestamp":1625472871000},"page":"2918-2924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["EVALI versus MIS\u2010C, one more overlapping diagnosis to consider"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4081-3618","authenticated-orcid":false,"given":"Diego A.","family":"Cruz\u2010Vidal","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-4058","authenticated-orcid":false,"given":"Eric S.","family":"Mull","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Taveras","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4938-9075","authenticated-orcid":false,"given":"Richard","family":"Shell","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garrett W.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Fowler","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Wallihan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-359X","authenticated-orcid":false,"given":"Guliz","family":"Erdem","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31094-1"},{"key":"e_1_2_9_3_1","unstructured":"Centers for Disease Control and Prevention. Multisystemic Inflammatory Syndrome in Children (MIS\u2010C) associated with Coronavirus Disease 2019 (COVID\u201019). CDC Health Alert Network; 2020.https:\/\/emergency.cdc.gov\/han\/2020\/han00432.asp. Accessed February 8 2021."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.06.029"},{"key":"e_1_2_9_5_1","unstructured":"Centers for Disease Control and Prevention. Health department\u2010reported cases of multisystem inflammatory syndrome in children (MIS\u2010C) in the United States.https:\/\/www.cdc.gov\/mis-c\/cases\/. Accessed February 8 2021."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6903e2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6932e2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2020.07.002"},{"key":"e_1_2_9_9_1","unstructured":"Centers for Disease Control and Prevention. CDC COVID data tracker; 2020.https:\/\/covid.cdc.gov\/covid-data-tracker\/cases_totalcases. Accessed November 11 2020."},{"key":"e_1_2_9_10_1","unstructured":"Centers for Disease Control and Prevention. Outbreak of lung injury associated with the use of E\u2010cigarette or vaping products; 2020.https:\/\/www.cdc.gov\/tobacco\/basic_information\/e-cigarettes\/severe-lung-disease.html. Accessed November 11 2020."}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25558","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T09:12:19Z","timestamp":1692954739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/ppul.25558"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25558","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,16]]},"assertion":[{"value":"2020-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}