{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:14:51Z","timestamp":1740104091640,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the respiratory functions of children with nephrotic syndrome (NS) by impulse oscillometry (IOS) and its correlation with spirometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010five NS patients aged 3\u201318 years were included as the study group and 40 healthy children of the same age formed the control group. Patients were divided into nephrotic phase (first attack and relapse) and remission. Demographic, anthropometric, and laboratory data of the children were recorded. Respiratory functions were evaluated by IOS and spirometry. Children over 6\u2010years old performed both IOS and spirometry while children under 6 years performed only IOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The R (R5%, R10%, R5\u201020), AX and Z5% values of IOS in patients with nephrotic phase were higher than remission patients and control group while spirometry indices of PEF% and MEF25\u201075% were lower. <jats:italic>Z<\/jats:italic> scores of MEF25\u201075 were significantly negatively correlated with <jats:italic>z<\/jats:italic> scores of R5, R10, Z5, and Fres while they were significantly positively correlated with <jats:italic>z<\/jats:italic> scores of <jats:italic>X<\/jats:italic> values (5,\u200910,\u200915, and 20\u2009Hz). <jats:italic>Z<\/jats:italic> scores of forced expiratory volume in 1\u2009\/forced vital capacity significantly negatively correlated with <jats:italic>z<\/jats:italic> scores of <jats:italic>R<\/jats:italic> values (R5, R10), Z5 and AX and positively correlated with <jats:italic>z<\/jats:italic> scores of <jats:italic>X<\/jats:italic> values (X5, X10, X15\u2009Hz).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated that respiratory functions measured by IOS and spirometry were affected at the time of nephrotic phase in NS patients. IOS, a novel method easily applicable even in small children, is a potentially valuable tool to detect this condition; given its good correlation with spirometry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25589","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T13:41:35Z","timestamp":1626874895000},"page":"3301-3309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Respiratory function in children with nephrotic syndrome: Comparative evaluation of impulse oscillometry and spirometry"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4040-7908","authenticated-orcid":false,"given":"Fatih","family":"Kilci","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep S.","family":"Uyan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Pulmonology, School of Medicine Ko\u00e7 University  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehtap E.","family":"\u00c7elak\u0131l","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Nephrology, School of Medicine Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Bek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Nephrology, School of Medicine Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.279"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80760-3"},{"key":"e_1_2_9_4_1","first-page":"349","article-title":"Absence of lung edema in nephrotic rats","volume":"108","author":"Rackow EC","year":"1986","journal-title":"J Lab Clin Med"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1627"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200605-642ST"},{"key":"e_1_2_9_7_1","first-page":"441","article-title":"Reference values of total respiratory resistance and reactance between 4 and 26 Hz in children and adolescents aged 4 \u201320 years","volume":"23","author":"Clement J","year":"1987","journal-title":"Bull Eur Physiopathol Respir"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2013.34.3641"},{"key":"e_1_2_9_9_1","first-page":"138","article-title":"How should oxygen supplementation be guided by pulse oximetry in children: do we know the level?","volume":"4","author":"Langley R","year":"2016","journal-title":"Front Pediatr"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.2183"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00753-2019"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.03374"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1089"},{"key":"e_1_2_9_15_1","first-page":"98","volume-title":"Pediatric Respiratory Disease","author":"Hilman BC","year":"1993"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.11.011"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01343.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-120004923"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00003407"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.09.022"},{"issue":"3","key":"e_1_2_9_21_1","first-page":"963","article-title":"Negative effects of nephrotic syndrome on pulmonary function test parameters","volume":"2","author":"Balaji PV","year":"2014","journal-title":"Sch. 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