{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:05:55Z","timestamp":1780470355814,"version":"3.54.1"},"reference-count":5,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Perinuclear anti\u2010neutrophil cytoplasmic antibodies (P\u2010ANCA) are associated with a multisystem vasculitis affecting small blood vessels in the body. A handful of adult patients who developed vasculitis post\u2010COVID\u201019 have been reported. Although SARS\u2010CoV\u20102 has been shown to drive an exaggerated immune response in the pediatric population, such as in Multisystem Inflammatory Syndrome in Children (MIS\u2010C), only one case of vasculitis following COVID\u201019 has been reported previously in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>Seventeen\u2010year\u2010old male with a past medical history of COVID\u201019 pneumonia two months prior presented with acute kidney injury and diffuse alveolar hemorrhage. Rheumatologic workup revealed P\u2010ANCA and Myeloperoxidase (MPO) positivity. Kidney biopsy showed necrotizing glomerulonephritis with limited immune complex deposition. Subsequently, he was treated with steroids and plasmapheresis, and ultimately started on cyclophosphamide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this report presents the second reported pediatric case of P\u2010ANCA\/MPO vasculitis following COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25612","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T20:53:00Z","timestamp":1628715180000},"page":"3422-3424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Pediatric P\u2010ANCA vasculitis following COVID\u201019"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2942-490X","authenticated-orcid":false,"given":"Yaron","family":"Fireizen","sequence":"first","affiliation":[{"name":"Pulmonary Division Memorial Care Miller Children's &amp; Women's Hospital  Long Beach California USA"},{"name":"School of Medicine University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Shahriary","sequence":"additional","affiliation":[{"name":"Pulmonary Division Memorial Care Miller Children's &amp; Women's Hospital  Long Beach California USA"},{"name":"School of Medicine University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Imperial","sequence":"additional","affiliation":[{"name":"Pulmonary Division Memorial Care Miller Children's &amp; Women's Hospital  Long Beach California USA"},{"name":"School of Medicine University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderpal","family":"Randhawa","sequence":"additional","affiliation":[{"name":"Pulmonary Division Memorial Care Miller Children's &amp; Women's Hospital  Long Beach California USA"},{"name":"School of Medicine University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastasia","family":"Nianiaris","sequence":"additional","affiliation":[{"name":"Pulmonary Division Memorial Care Miller Children's &amp; Women's Hospital  Long Beach California USA"},{"name":"School of Medicine University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bugsu","family":"Ovunc","sequence":"additional","affiliation":[{"name":"Pulmonary Division Memorial Care Miller Children's &amp; Women's Hospital  Long Beach California USA"},{"name":"School of Medicine University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11080762"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102506"},{"issue":"45","key":"e_1_2_9_4_1","first-page":"e1","article-title":"Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review [published online ahead of print, 2020 Aug 5]","volume":"226","author":"Abrams JY","year":"2020","journal-title":"J Pediatr"},{"issue":"8","key":"e_1_2_9_5_1","first-page":"e9643","article-title":"Anti\u2010neutrophilic cytoplasmic antibody (ANCA) vasculitis presented as pulmonary hemorrhage in a positive COVID\u201019 patient: a case report","volume":"12","author":"Hussein A","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-033092"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25612","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T19:36:17Z","timestamp":1693337777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":5,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/ppul.25612"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25612","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,11]]},"assertion":[{"value":"2021-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}