{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:14:52Z","timestamp":1740104092315,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the impact of human milk and different neonatal variables on tidal breathing flow\u2010volume loop (TBFVL) parameters within three months' corrected age (CA) in infants born \u226432 wks or weighing &lt;1500\u2009g.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied 121 infants with gestational age (GA)\u2009\u2264\u200932 weeks or birth weight (BW)\u2009&lt;1500 gr who had lung function assessment within three months' CA by TBFVL analysis between June 2009 and April 2018.<\/jats:p><jats:p>We investigated the impact of GA, gender, being Small for GA (SGA), sepsis, days of mechanical ventilation (MV) and human milk feeding (HMF) on later respiratory function, both in the entire group and according to BW (\u2009\u22641000\u2009g and &gt;1000\u2009g).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean(SD) z\u2010score for tidal volume (Vt) and time to peak expiratory flow to expiratory time (tPTEF\/tE) were respectively \u22124.3 (2.5) and \u22120.8 (2.0) for the overall population with no significant differences between infants &lt;1000\u2009g or \u22651000\u2009g. The mean(SD) Vt standardized for body weight was 6.2(2.0) ml\/kg.<\/jats:p><jats:p>Being female was associated with better Vt\/Kg, whereas longer MV or being born SGA were associated with worst tPTEF\/tE. For infants with BW\u2009&lt;\u20091000\u2009gr, tPTEF\/tE was positively associated with HMF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An early TBFVL assessment within three months' CA already reveals lung function alteration in preterm infants. Being female is associated with better Vt\/Kg, while longer duration of MV or being born SGA negatively affect tPTEF\/tE. The positive association between HMF and better tPTEF\/tE in infants with BW &lt;1000\u2009g has emerged, which deserves further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25625","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T19:08:57Z","timestamp":1629313737000},"page":"3832-3838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of human milk and other neonatal variables on lung function at three months corrected age"],"prefix":"10.1002","volume":"56","author":[{"given":"Francesco","family":"Beretta","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico  Milan 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