{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:33:15Z","timestamp":1789605195760,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007148","name":"Bundesministerium f\u00fcr Wissenschaft und Forschung","doi-asserted-by":"publisher","award":["NWG VH\u2010NG\u2010829"],"award-info":[{"award-number":["NWG VH\u2010NG\u2010829"]}],"id":[{"id":"10.13039\/501100007148","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Despite the routine use of antenatal steroids, exogenous surfactants, and different noninvasive ventilation methods, many extremely low gestational age neonates, preterm, and term infants eventually require invasive ventilation. In addition to prematurity, mechanical ventilation itself can induce ventilator\u2010induced lung injury leading to lifelong pulmonary sequelae. Besides conventional mechanical ventilation, high\u2010frequency oscillatory ventilation (HFOV) with tidal volumes below dead space and high ventilation frequencies is used either as a primary or rescue therapy in severe neonatal respiratory failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Applying a high\u2010resolution computational lung modeling technique in a preterm infant, we studied three different high\u2010frequency ventilation settings as well as conventional ventilation (CV) settings. Evaluating the computed oxygen delivery (OD) and lung mechanics (LM) we outline for the first time how changing ventilator settings from CV to HFOV lead to significant improvements in OD and LM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This personalized \u201cdigital twin\u201d strategy advances our general knowledge of protective ventilation strategies in neonatal care and can support decisions on various modes of ventilatory therapy at high frequencies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25626","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T20:35:20Z","timestamp":1629923720000},"page":"3839-3846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["In silico numerical simulation of ventilator settings during high\u2010frequency ventilation in preterm infants"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-1400","authenticated-orcid":false,"given":"Kai M.","family":"F\u00f6rster","sequence":"first","affiliation":[{"name":"Division of Neonatology, Dr. von Hauner Children's Hospital LMU University Hospital Munich  Munich Germany"},{"name":"Institute for Lung Biology and Disease and Comprehensive Pneumology Center with the CPC\u2010M bioArchive  Helmholtz Zentrum M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.","family":"Roth","sequence":"additional","affiliation":[{"name":"Institute for Computational Mechanics Technical University of Munich  Garching Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Hilgendorff","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Dr. von Hauner Children's Hospital LMU University Hospital Munich  Munich Germany"},{"name":"Institute for Lung Biology and Disease and Comprehensive Pneumology Center with the CPC\u2010M bioArchive  Helmholtz Zentrum M\u00fcnchen Germany"},{"name":"Center for Comprehensive Developmental Care (CDeCLMU) LMU University Hospital Munich  Munich 80337 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Ertl\u2010Wagner","sequence":"additional","affiliation":[{"name":"Department of Radiology LMU University Hospital Munich  Munich Germany"},{"name":"Department of Diagnostic Imaging The Hospital for Sick Children  Toronto Canada"},{"name":"Department of Medical Imaging University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas W.","family":"Flemmer","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Dr. von Hauner Children's Hospital LMU University Hospital Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang 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