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Associations between clinical and laboratory risk factors\/biomarkers of BPD and CRM were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 86 subjects, 94% survived. Outcomes were available for 89% at 36\u2010week PMA (BPD present in 42% of infants) and 72% at 6\u201312\u2010month CGA (CRM present in 47% of infants). For the 54 infants with known outcomes for both BPD and CRM, diagnoses were discordant in 41%. BPD was associated with lower birthweight and birthweight Z\u2010score for GA, lower Apgar scores, more surfactant doses, higher SNAPPE\u2010II scores, highest Day 1 inspired oxygen concentration, Day 7 oxygen use, prolonged ventilatory support, bacteremia, necrotizing enterocolitis, and treated patent ductus arteriosus. CRM was associated with lower Apgar scores, Day 7 oxygen use and higher urine vascular endothelial growth factor. Patterns of plasma and urine lipid oxidation products differed in the two outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this hypothesis generating and exploratory study, BPD and CRM were associated with different risk factors\/biomarker patterns. Concordance between these two outcomes was weak. Strategies for reducing CRM should be studied in cohorts identified by appropriate early risk factors\/biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25630","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T19:42:17Z","timestamp":1630006937000},"page":"3847-3856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differences in clinical and laboratory biomarkers for short and long\u2010term respiratory outcomes in preterm neonates"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-0609","authenticated-orcid":false,"given":"Richard B.","family":"Parad","sequence":"first","affiliation":[{"name":"Department of Pediatric Newborn Medicine, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis L.","family":"Breeze","sequence":"additional","affiliation":[{"name":"Tufts Clinical and Translational Science Institute Biostatistics, Epidemiology and Research Design (BERD) Center Tufts University and the Institute for Clinical Research and Health Policy Studies, Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Terrin","sequence":"additional","affiliation":[{"name":"Tufts Clinical and Translational Science Institute Biostatistics, Epidemiology and Research Design (BERD) Center Tufts University and the Institute for Clinical Research and Health Policy Studies, Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette K.","family":"Rogers","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Perinatal Research Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"Salafia","sequence":"additional","affiliation":[{"name":"Department of Pathology New York Methodist Hospital  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-5349","authenticated-orcid":false,"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[{"name":"Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Tufts Clinical and Translational Science Institute Biostatistics, Epidemiology and Research Design (BERD) Center Tufts University and the Institute for Clinical Research and Health Policy Studies, Tufts Medical Center  Boston Massachusetts USA"},{"name":"Department of Pediatrics Tufts Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.04.026"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.110"},{"issue":"8","key":"e_1_2_9_4_1","first-page":"1","article-title":"Births: final data for 2017","volume":"67","author":"Martin JA","year":"2018","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.08.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10244"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369878"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.19"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.08.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0249"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.01.043"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.109608"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2016.1156668"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.055"},{"issue":"2","key":"e_1_2_9_17_1","first-page":"293","article-title":"Synthesis of 5\u2010oxo\u20106,8,11,14\u2010eicosatetraenoic acid and identification of novel omega\u2010oxidized metabolites in the mouse macrophage","volume":"296","author":"Hevko JM","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_9_18_1","unstructured":"EicosanoidsRH.http:\/\/www.lipidmaps.org. 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