{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T10:32:31Z","timestamp":1724668351145},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic bronchopulmonary aspergillosis (ABPA) complicating cystic fibrosis (CF) is frequently associated with significant structural lung damage as assessed by computed tomography (CT) scanning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a validated CF scoring system (structural lung disease [SLD]\u00a0score) we examined the degree of structural lung disease in a group of 25 children with CF who had received steroid therapy for ABPA (CF\u2010ABPA) and compared our findings to a matched group of CF patients without ABPA (CF\u2010CON) using both cross\u2010section and longitudinal analysis. Further, we examined the structure\u2013function correlation between CT findings and lung function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean SLD score (expressed as a percentage of maximal score) was significantly higher (worse) in the CF\u2010ABPA group than the CF\u2010CON group (29.3% CF\u2013ABPA vs. 18.7% CF\u2010CON <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). CF\u2010ABPA patients showed significantly greater rate of development of structural lung disease over time than CF\u2010CON patients (6.8% per year vs 1.4% <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). We found no correlation between lung function and the degree of structural lung disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ABPA in children with CF is associated with significantly more structural lung disease than that found in children with CF without ABPA. Despite interventive steroid therapy lung disease progresses more rapidly in those patients with ABPA and CF than control patients with CF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25641","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T13:59:30Z","timestamp":1629813570000},"page":"3737-3744","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Structural lung disease following allergic bronchopulmonary aspergillosis complicating pediatric cystic fibrosis"],"prefix":"10.1002","volume":"56","author":[{"given":"Angus","family":"McCashney","sequence":"first","affiliation":[{"name":"Department of Paediatrics The University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The University of Melbourne Melbourne Australia"},{"name":"Department of Respiratory and Sleep Medicine Royal Children's Hospital Melbourne Australia"},{"name":"Infection and Immunity Murdoch Children's Research Institute Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.130179"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"237","article-title":"Allergic bronchopulmonary aspergillosis","volume":"7","author":"Patterson K","year":"2010","journal-title":"Society"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-423OC"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/376525"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpradiol.2015.07.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-007-0471-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017162350"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/028418519103200601"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.165.2.7618537"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.3.2027992"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.02.038"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.110908"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950110112"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.02.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210917"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(97)90041-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0808"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015346"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034505"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.045146"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.05.047"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25641","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T13:37:25Z","timestamp":1692970645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,9]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/ppul.25641"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25641","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,9]]},"assertion":[{"value":"2020-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}