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In my time as a pediatric respiratory physician, I have borne witness to remarkable advances in treatment that have changed patients' fortunes overnight. Examples of these include artificial surfactant replacement for premature newborns, conjugate Haemophilus influenzae type b vaccination, propranolol for infants with subglottic haemangiomas, mandibular distraction for babies with micrognathia, cystic fibrosis transmembrane conductance regulator modulators therapy for patients with cystic fibrosis, and antisense oligonucleotide therapy for infants with spinal muscular atrophy. There are lessons to be learned from reflection upon these life\u2010transforming treatments, and perhaps it is a good time just to pause and wonder.<\/jats:p>","DOI":"10.1002\/ppul.25693","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T11:47:03Z","timestamp":1632397623000},"page":"3586-3591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Miracles in my time: Reflections of a pediatric respiratory physician"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1008-0967","authenticated-orcid":false,"given":"John","family":"Massie","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Children's Bioethics Centre Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Melbourne Victoria Australia"},{"name":"Infection, immunity and Environment Theme Murdoch Children's Research Institute Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"issue":"7","key":"e_1_2_5_2_1","first-page":"745","article-title":"Chronic lung disease after premature birth","volume":"358","author":"Kiren V","year":"2008","journal-title":"N Engl J Med"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1016\/S0022-3476(05)80502-5"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1056\/NEJM199112123252404"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_1","DOI":"10.1542\/peds.85.4.631"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1111\/j.1445-5994.2005.00909.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1001\/jama.1993.03500020055031"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.1177\/019459989310900413"},{"doi-asserted-by":"publisher","key":"e_1_2_5_9_1","DOI":"10.1016\/0165-5876(91)90094-R"},{"doi-asserted-by":"publisher","key":"e_1_2_5_10_1","DOI":"10.1002\/ppul.10426"},{"doi-asserted-by":"publisher","key":"e_1_2_5_11_1","DOI":"10.1097\/PRS.0000000000004581"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_1","DOI":"10.1136\/adc.65.1.123"},{"doi-asserted-by":"publisher","key":"e_1_2_5_13_1","DOI":"10.1056\/NEJMc0708819"},{"doi-asserted-by":"publisher","key":"e_1_2_5_14_1","DOI":"10.1016\/j.ijporl.2009.08.020"},{"doi-asserted-by":"publisher","key":"e_1_2_5_15_1","DOI":"10.1016\/S0140-6736(16)00645-0"},{"doi-asserted-by":"publisher","key":"e_1_2_5_16_1","DOI":"10.1056\/NEJMoa1908639"},{"doi-asserted-by":"publisher","key":"e_1_2_5_17_1","DOI":"10.1056\/NEJMoa1807119"},{"doi-asserted-by":"publisher","key":"e_1_2_5_18_1","DOI":"10.1111\/jpc.15517"},{"doi-asserted-by":"publisher","key":"e_1_2_5_19_1","DOI":"10.1002\/humu.10041"},{"key":"e_1_2_5_20_1","first-page":"1","article-title":"A review of treatments that improve cystic fibrosis transmembrane conductance regulator function","volume":"9","author":"Shanthikumar S","year":"2017","journal-title":"Clin Med Insights Ther"},{"doi-asserted-by":"publisher","key":"e_1_2_5_21_1","DOI":"10.1016\/j.ncl.2015.07.004"},{"doi-asserted-by":"publisher","key":"e_1_2_5_22_1","DOI":"10.1111\/jpc.12291"},{"doi-asserted-by":"publisher","key":"e_1_2_5_23_1","DOI":"10.1111\/j.1440-1754.2007.01052.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_24_1","DOI":"10.1111\/jpc.12386"},{"doi-asserted-by":"publisher","key":"e_1_2_5_25_1","DOI":"10.1056\/NEJMoa1702752"},{"issue":"223","key":"e_1_2_5_26_1","article-title":"Respiratory needs in patients with type 1 spinal muscular atrophy treated with nusinersen","volume":"219","author":"Sansone VA","year":"2020","journal-title":"J Pediatr"},{"doi-asserted-by":"publisher","key":"e_1_2_5_27_1","DOI":"10.1038\/nrneurol.2018.4"},{"doi-asserted-by":"publisher","key":"e_1_2_5_28_1","DOI":"10.1016\/j.ejpn.2020.07.001"},{"doi-asserted-by":"publisher","key":"e_1_2_5_29_1","DOI":"10.1016\/j.pedneo.2016.09.011"},{"doi-asserted-by":"publisher","key":"e_1_2_5_30_1","DOI":"10.1016\/S2213-2600(17)30124-8"},{"doi-asserted-by":"publisher","key":"e_1_2_5_31_1","DOI":"10.1016\/j.iac.2018.12.012"},{"doi-asserted-by":"publisher","key":"e_1_2_5_32_1","DOI":"10.1056\/NEJM199409083311003"},{"issue":"4","key":"e_1_2_5_33_1","article-title":"Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis","volume":"4","author":"Langton Hewer SC","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"doi-asserted-by":"publisher","key":"e_1_2_5_34_1","DOI":"10.1016\/j.prrv.2018.09.001"},{"doi-asserted-by":"publisher","key":"e_1_2_5_35_1","DOI":"10.1111\/jpc.13500"},{"unstructured":"The History of Vaccines. 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