{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:32:52Z","timestamp":1776879172950,"version":"3.51.2"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871656"],"award-info":[{"award-number":["81871656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81922011"],"award-info":[{"award-number":["81922011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Few studies have explored the clinical features in children infected with SARS\u2010CoV\u20102 and other common respiratory viruses, including respiratory syncytial virus (RSV), Influenza virus (IV), and adenovirus (ADV). Herein, we reported the clinical characteristics and cytokine profiling in children with COVID\u201019 or other acute respiratory tract infections (ARTI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 20 hospitalized children confirmed as COVID\u201019 positive, 58 patients with ARTI, and 20 age and sex\u2010matched healthy children. The clinical information and blood test results were collected. A total of 27 cytokines and chemokines were measured and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age in the COVID\u201019 positive group was 14.5 years, which was higher than that of the ARTI groups. Around one\u2010third of patients in the COVID\u201019 group experienced moderate fever, with a peak temperature of 38.27\u00b0C. None of the patients displayed wheezing or dyspnea. In addition, patients in the COVID\u201019 group had lower white blood cells, platelet counts as well as a neutrophil\u2010lymphocyte ratio. Lower serum concentrations of 14 out of 27 cytokines were observed in the COVID\u201019 group than in healthy individuals. Seven cytokines (IL\u20101Ra, IL\u20101\u03b2, IL\u20109, IL\u201010, TNF\u2010\u03b1, MIP\u20101\u03b1, and VEGF) changed serum concentration in COVID\u201019 compared with other ARTI groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with COVID\u201019 were older and showed milder symptoms and a favorable prognosis than ARTI caused by RSV, IV, and ADV. There was a low grade or constrained innate immune reaction in children with mild COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25700","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T12:43:17Z","timestamp":1632487397000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical features of Chinese children with COVID\u201019 and other viral respiratory infections"],"prefix":"10.1002","volume":"57","author":[{"given":"Zhen\u2010Zhen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders The Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da\u2010Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, National Clinical Research Center for Child Health and Disorders The Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan\u2010Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders The Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders The Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders The Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Clinical Research Center for Child Health and Disorders The Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia\u2010Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders The Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Mei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders The Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai\u2010Long","family":"Huang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Department of Infectious Diseases Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan\u2010Xin","family":"Long","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Department of Infectious Diseases Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Jun","family":"Deng","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Department of Infectious Diseases Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6920-7972","authenticated-orcid":false,"given":"Juan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders The Children's Hospital of Chongqing Medical University Chongqing China"},{"name":"The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Department of Infectious Diseases Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Coronavirus disease (COVID\u201019) outbreak situation; 2020. 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