{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:42:55Z","timestamp":1780602175711,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nasal nitric oxide (nNO) measurement is recommended as a first line screening test for primary ciliary dyskinesia (PCD). While reliable velum\u2010 and non\u2010velum\u2010closure techniques exist for preschool children and older individuals, no data are available for neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine feasibility of nNO screening and nNO concentration in healthy newborns in the first week of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nasal NO was analyzed in tidal breathing during natural sleep using a CLD\u201088 sp NO analyzer (chemoluminescence sensor) and a NIOX MINO (electrochemical sensor). Test success and nNO concentration were determined and compared between the two devices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nasal NO was measured in 62 healthy neonates within the first week of life. Feasibility of nNO measurement was 100% for at least one nostril and 85.5% for both nostrils using the chemoluminescence device, but significantly lower with the electrochemical device (85.5% and 53.2%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Median nNO concentration was 38 ppb (interquartile range, 27\u201355; range, 9\u2013100) with the ECOMEDICS device and 23 (15\u201333, 8\u201359) with the NIOX MINO (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), with a trend towards higher values for older subjects. None of the subjects exceeded nNO levels of 100 ppb.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Measurement of nNO using a chemoluminescence device is highly feasible in newborns during natural sleep. However, nNO levels are considerably lower compared to the published data for older individuals and in the range of a PCD reference group of infants between 4 and 8 weeks of age, potentially resulting in a great overlap with subjects with PCD in this age group. Therefore, screening for PCD using nasal NO might not be useful in the first week of life. Upon clinical suspicion, other diagnostic tests such as high\u2010speed video analysis of the cilia should be applied.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.25702","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T21:13:55Z","timestamp":1632777235000},"page":"231-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Feasibility of nasal NO screening in healthy newborns"],"prefix":"10.1002","volume":"57","author":[{"given":"Flurina","family":"Buechel","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine &amp; Children's Research Centre University Children's Hospital Zurich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9987-2866","authenticated-orcid":false,"given":"Jakob","family":"Usemann","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine &amp; Children's Research Centre University Children's Hospital Zurich"},{"name":"University Children's Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Aline","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine &amp; Children's Research Centre University Children's Hospital Zurich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Salfeld","sequence":"additional","affiliation":[{"name":"Kantonsspital Muensterlingen  M\u00fcnsterlingen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-4251","authenticated-orcid":false,"given":"Alexander","family":"Moeller","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine &amp; Children's Research Centre University Children's Hospital Zurich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-6691","authenticated-orcid":false,"given":"Andreas","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine &amp; Children's Research Centre University Children's Hospital Zurich"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2016.04.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01090-2016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13630-014-0011-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02018-2015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01551-2015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201904-347OT"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00176608"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00749-2015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00088614"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-18"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23167"},{"issue":"56","key":"e_1_2_8_13_1","article-title":"Diagnostic value of nasal NO measurement using the NIOX MINO device","volume":"40","author":"Jung A","year":"2012","journal-title":"Eur Respir J"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057262"},{"key":"e_1_2_8_15_1","first-page":"5","article-title":"Nasal nitrite oxide measurement in preschool children: feasibility and validation of a tidal breathing technique with a straw","volume":"82","author":"Jung A","year":"2011","journal-title":"Respiration"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.07.010"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2472"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.03.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02503-2017"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.086702"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00001010"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.25702","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.25702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:52:01Z","timestamp":1692967921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.25702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/ppul.25702"],"URL":"https:\/\/doi.org\/10.1002\/ppul.25702","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2020-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}